Toward an Effective Ebola Virus Vaccine

Long-term control of viral outbreaks requires the use of vaccines to impart acquired resistance and ensuing protection. In the wake of an epidemic, established immunity against a particular disease can limit spread and significantly decrease mortality. Creation of a safe and efficacious vaccine agai...

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Published inAnnual review of medicine Vol. 68; no. 1; pp. 371 - 386
Main Authors Keshwara, Rohan, Johnson, Reed F, Schnell, Matthias J
Format Journal Article
LanguageEnglish
Published United States Annual Reviews 14.01.2017
Annual Reviews, Inc
Subjects
Adenoviridae
Animals
Biomedical Research
Disease transmission
Drug Discovery
Ebola Vaccines
Ebola virus
Ebolavirus
Ebolavirus - immunology
EBOV vaccine
Epidemics
Filovirus
Hemorrhagic Fever, Ebola - prevention & control
Humans
immunization
Immunization, Passive
Mortality
Nanoparticles
Rabies virus
Vaccination
Vaccines
Vaccines, DNA
Vaccines, Synthetic
Vaccines, Virus-Like Particle
vector
Vesiculovirus
EBOV vaccine
immunization
vector
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Summary:Long-term control of viral outbreaks requires the use of vaccines to impart acquired resistance and ensuing protection. In the wake of an epidemic, established immunity against a particular disease can limit spread and significantly decrease mortality. Creation of a safe and efficacious vaccine against Ebola virus (EBOV) has proven elusive so far, but various inventive strategies are now being employed to counteract the threat of outbreaks caused by EBOV and related filoviruses. Here, we present a current overview of progress in the field of Ebola virus vaccine development.
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ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-051215-030919