New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from simple, readily available feedstocks have become a cornerstone of modern synthetic organic chemistry. In light of the ever-increasing importance of aliphatic amines across the range of chemical sciences, th...

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Published inChemical reviews Vol. 120; no. 5; pp. 2613 - 2692
Main Authors Trowbridge, Aaron, Walton, Scarlett M, Gaunt, Matthew J
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.03.2020
Subjects
Aliphatic amines
Alkylamines
Amines
Catalysis
Chemical bonds
Chemical reactions
Chemical synthesis
Metals
Organic chemistry
Photoredox catalysis
Transition metals
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Summary:Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from simple, readily available feedstocks have become a cornerstone of modern synthetic organic chemistry. In light of the ever-increasing importance of aliphatic amines across the range of chemical sciences, this review aims to provide a concise overview of modern transition-metal catalyzed approaches to alkylamine synthesis and their functionalization. Selected examples of amine bond forming reactions include: (a) hydroamination and hydroaminoalkylation, (b) transition-metal catalyzed C­(sp3)–H functionalization, and (c) transition-metal catalyzed visible-light-mediated light photoredox catalysis.
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ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.9b00462