Novel Radiotracer for ImmunoPET Imaging of PD‑1 Checkpoint Expression on Tumor Infiltrating Lymphocytes

• Published in: Bioconjugate chemistry Vol. 26; no. 10; pp. 2062 - 2069
• Main Authors: Natarajan, Arutselvan, Mayer, Aaron T, Xu, Lingyun, Reeves, Robert E, Gano, Jacob, Gambhir, Sanjiv S
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.10.2015
• Subjects: Animals; Antibodies, Monoclonal - chemistry; Cell Death - immunology; Copper Radioisotopes - chemistry; Gene expression; Heterocyclic Compounds - chemistry; Immunoconjugates - chemistry; Immunoconjugates - pharmacokinetics; Immunotherapy; Isothiocyanates - chemistry; Liquid chromatography; Lymphocytes; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - pathology; Melanoma; Melanoma - pathology; Mice, Transgenic; Positron-Emission Tomography - methods; Programmed Cell Death 1 Receptor - immunology; Programmed Cell Death 1 Receptor - metabolism; Quality control; Radioactive tracers; Radiopharmaceuticals - pharmacokinetics; Rodents; Tissue Distribution; Tumors; Xenograft Model Antitumor Assays

Immune checkpoint signaling through the programmed death 1 (PD-1) axis to its ligand (PD-L1) significantly dampens anti-tumor immune responses. Cancer patients treated with checkpoint inhibitors that block this suppressive signaling have exhibited objective response rates of 20–40% for advanced soli...