T cell trafficking in allergic asthma: the ins and outs

T cells are critical mediators of the allergic airway inflammation seen in asthma. Pathogenic allergen-specific T cells are generated in regional lymph nodes and are then recruited into the airway by chemoattractants produced by the asthmatic lung. These recruited effector T cells and their products...

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Bibliographic Details
Published inAnnual review of immunology Vol. 26; p. 205
Main Authors Medoff, Benjamin D, Thomas, Seddon Y, Luster, Andrew D
Format Journal Article
LanguageEnglish
Published United States 01.01.2008
Subjects
Animals
Asthma - immunology
Asthma - pathology
Chemokines - immunology
Chemotaxis - immunology
Humans
Lung - cytology
Lung - immunology
Lymph Nodes - cytology
Lymph Nodes - immunology
Models, Immunological
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:T cells are critical mediators of the allergic airway inflammation seen in asthma. Pathogenic allergen-specific T cells are generated in regional lymph nodes and are then recruited into the airway by chemoattractants produced by the asthmatic lung. These recruited effector T cells and their products then mediate the cardinal features of asthma: airway eosinophilia, mucus hypersecretion, and airway hyperreactivity. There has been considerable progress in delineating the molecular mechanisms that control T cell trafficking into peripheral tissue, including the asthmatic lung. In this review, we summarize these advances and formulate them into a working model that proposes that T cell trafficking into and out of the allergic lung is controlled by several discrete regulatory pathways that involve the collaboration of innate and acquired immune cells.
ISSN:0732-0582
DOI:10.1146/annurev.immunol.26.021607.090312