Stereoselective Syntheses of Pentose Sugars Under Realistic Prebiotic Conditions
Glycolaldehyde and dl-glyceraldehyde reacted in a water-buffered solution under mildly acidic conditions and in the presence of chiral dipeptide catalysts produced pentose sugars whose configuration is affected by the chirality of the catalyst. The chiral effect was found to vary between catalysts a...
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Published in | Origins of life and evolution of biospheres Vol. 40; no. 1; pp. 3 - 10 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Dordrecht : Springer Netherlands
01.02.2010
Springer Netherlands Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Glycolaldehyde and dl-glyceraldehyde reacted in a water-buffered solution under mildly acidic conditions and in the presence of chiral dipeptide catalysts produced pentose sugars whose configuration is affected by the chirality of the catalyst. The chiral effect was found to vary between catalysts and to be largest for di-valine. Lyxose, arabinose, ribose and xylose are formed in different amounts, whose relative proportions do not change significantly with the varying of conditions. With LL-peptide catalysts, ribose was the only pentose sugar to have a significant D-enantiomeric excess (ee) (≤44%), lyxose displayed an L-ee of ≤66%, arabinose a smaller L-ee of ≤8%, and xylose was about racemic. These data expand our previous findings for tetrose sugars and further substantiate the suggestion that interactions between simple molecules of prebiotic relevance on the early Earth might have included the transfer of chiral asymmetry and advanced molecular evolution. |
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Bibliography: | http://dx.doi.org/10.1007/s11084-009-9178-1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0169-6149 1573-0875 |
DOI: | 10.1007/s11084-009-9178-1 |