The Synthesis and Biological Characterization of a Ceramide Library

• Published in: Journal of the American Chemical Society Vol. 124; no. 9; pp. 1856 - 1857
• Main Authors: Chang, Young-Tae, Choi, Jaehwa, Ding, Sheng, Prieschl, Eva E, Baumruker, Thomas, Lee, Jae-Mok, Chung, Sung-Kee, Schultz, Peter G
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 06.03.2002; Amer Chemical Soc
• Subjects: Apoptosis - drug effects; Biological and medical sciences; Ceramides - chemical synthesis; Ceramides - chemistry; Ceramides - pharmacology; Ceramides - physiology; Chemistry; Chemistry, Multidisciplinary; Combinatorial Chemistry Techniques; General pharmacology; Humans; Medical sciences; Pharmacology. Drug treatments; Physical Sciences; Physicochemical properties. Structure-activity relationships; Science & Technology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; U937 Cells; APOPTOSIS; ACTIVATION; MEDIATED BIOLOGY; STRESS; NF-KAPPA-B; Combinatorial chemistry; Sphingolipid; Lipids; Ketone; Biological activity; Signal transduction; Acyl group; Cell death; Chemical compound library; Ceramide; Transcription factor NFκB; Solid phase; Chemical synthesis; Apoptosis
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja017576o

A facile synthesis of a combinatorial ceramide library and their activities in the NF-κB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-κB activating molecule was discovered among ceramide containing β-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.