Englerins: A Comprehensive Review

• Published in: Journal of natural products (Washington, D.C.) Vol. 80; no. 3; pp. 771 - 781
• Main Authors: Wu, Zhenhua, Zhao, Senzhi, Fash, David M, Li, Zhenwu, Chain, William J, Beutler, John A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society and American Society of Pharmacognosy 24.03.2017
• Subjects: Antineoplastic Agents, Phytogenic; clinical trials; Humans; kidney neoplasms; Kidney Neoplasms - drug therapy; Molecular Structure; Sesquiterpenes, Guaiane

In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further...