Englerins: A Comprehensive Review

In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further...

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 80; no. 3; pp. 771 - 781
Main Authors Wu, Zhenhua, Zhao, Senzhi, Fash, David M, Li, Zhenwu, Chain, William J, Beutler, John A
Format Journal Article
LanguageEnglish
Published United States American Chemical Society and American Society of Pharmacognosy 24.03.2017
Subjects
Antineoplastic Agents, Phytogenic
clinical trials
Humans
kidney neoplasms
Kidney Neoplasms - drug therapy
Molecular Structure
Sesquiterpenes, Guaiane
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Summary:In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.
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Incyte Corporation, 1801 Augustine Cutoff;, Wilmington, Delaware 19803, United States.
Abzena−Bristol PA, 360 George Patterson Boulevard, Suite 101E, Bristol, Pennsylvania 19007, United States.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.6b01167