Luliconazole Demonstrates Potent In Vitro Activity against Dermatophytes Recovered from Patients with Onychomycosis

• Published in: Antimicrobial agents and chemotherapy Vol. 58; no. 6; pp. 3553 - 3555
• Main Authors: WIEDERHOLD, Nathan P, FOTHERGILL, Annette W, MCCARTHY, Dora I, TAVAKKOL, Amir
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2014
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - pharmacology; Arthrodermataceae; Arthrodermataceae - drug effects; Biological and medical sciences; Dermatomycoses; Dermatomycoses - complications; Dermatomycoses - drug therapy; Human mycoses; Humans; Imidazoles; Imidazoles - pharmacology; Infectious diseases; Medical sciences; Microbial Sensitivity Tests; Morpholines - pharmacology; Mycoses; Mycoses of the skin; Naphthalenes - pharmacology; Onychomycosis; Onychomycosis - complications; Onychomycosis - microbiology; Pharmacology. Drug treatments; Pyridones - pharmacology; Susceptibility; Infection; Human; Skin disease; Antifungal agent; Mycosis; Nail disease; Patient; In vitro; Biological activity; Dermatophyte; Luliconazole; Onychomycosis
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.02706-13

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.