Plasma Levels of MCP-1 and Adiponectin in Obstructive Sleep Apnea Syndrome

• Published in: Archives of otolaryngology--head & neck surgery Vol. 136; no. 9; pp. 896 - 899
• Main Authors: Kim, Joohwan, Lee, Chang Hoon, Park, Chan Soon, Kim, Byung Guk, Kim, Soo Whan, Cho, Jin Hee
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.09.2010
• Subjects: Adiponectin - blood; Adult; Biological and medical sciences; Chemokine CCL2 - blood; Cytokines; Female; Humans; Immunoassay; Interleukin-6 - blood; Interleukin-8 - blood; Male; Medical sciences; Otolaryngology; Otorhinolaryngology. Stomatology; Plasma; Pneumology; Polysomnography; Proteins; Radioimmunoassay; Respiratory system : syndromes and miscellaneous diseases; Sleep apnea; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - physiopathology; Tissues; Tumor Necrosis Factor-alpha - blood; Nervous system diseases; Sleep apnea syndrome; Respiratory disease; Blood plasma
• ISSN: 0886-4470; 2168-6181; 1538-361X; 2168-619X
• DOI: 10.1001/archoto.2010.142

OBJECTIVES To evaluate the correlation between concentrations of the proinflammatory cytokines monocyte chemotactic protein 1 (MCP-1), adiponectin, interleukin 6 (IL-6), interleukin 8 (IL-8), and tumor necrosis factor (TNF) and patients with obstructive sleep apnea syndrome (OSAS). Repeated apnea attacks in patients with OSAS constitute a hypoxic condition, which induces tissue inflammation by mediation of these proinflammatory cytokines. DESIGN Radioimmunoassay analyses of nonrandomized controlled trial. SETTING University-affiliated tertiary care hospital. PATIENTS The study population comprised 59 patients who underwent the polysomnography. MAIN OUTCOME MEASURES Serum concentrations of MCP-1, adiponectin, IL-6, IL-8, and TNF, as well as body mass index and polysomnographic data, including apnea-hypopnea index (AHI) and lowest oxygen saturation. RESULTS The mean (SD) plasma level of MCP-1 in serum was increased in all patients with OSAS (P < .001), while adiponectin level was decreased in the patients with severe OSAS (6.88 [1.78] μg/mL) compared with normal controls (8.90 [2.63] μg/mL) (P = .006). Serum concentrations of IL-6, IL-8, and TNF did not exhibit any differences between patients with OSAS and normal controls. The correlation coefficient between plasma MCP-1 level and AHI was 0.62 and between adiponectin level and AHI was 0.66. CONCLUSIONS Our results suggest that plasma MCP-1 and adiponectin levels were different between patients with OSAS and normal controls. Adiponectin and MCP-1 may be prognostic factors for comparing patients with OSAS before and after treatment.Arch Otolaryngol Head Neck Surg. 2010;136(9):896-899-->