Mechanism of Resistance to an Antitubercular 2-Thiopyridine Derivative That Is Also Active against Burkholderia cenocepacia

The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activ...

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Published inAntimicrobial agents and chemotherapy Vol. 58; no. 4; pp. 2415 - 2417
Main Authors SCOFFONE, Viola C, SPADARO, Francesca, UDINE, Claudia, MAKAROV, Vadim, FONDI, Marco, FANI, Renato, DE ROSSI, Edda, RICCARDI, Giovanna, BURONI, Silvia
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2014
Subjects
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Antitubercular Agents
Antitubercular Agents - pharmacology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Burkholderia
Burkholderia cenocepacia
Burkholderia cenocepacia - drug effects
Burkholderia cenocepacia - genetics
Burkholderia cenocepacia - metabolism
Drug Resistance, Bacterial - genetics
Mechanisms of Resistance
Mycobacterium tuberculosis
Pyridines
Pyridines - pharmacology
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Summary:The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B. cenocepacia antibiotic resistance.
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ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02438-13