Small plasmids are involved in amoxicillin-clavulanate resistance in Escherichia coli
The introduction of beta -lactamase inhibitors (clavulanate, sulbactam, or tazobactam) in association with beta-lactam antibiotics is one of the current strategies to overcome bacterial resistance. Unfortunately, beta -lactamases are also "inhibitors" of these new compounds. In Escherichia...
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Published in | Antimicrobial agents and chemotherapy Vol. 33; no. 4; p. 595 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Society for Microbiology
01.04.1989
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Subjects | |
Online Access | Get full text |
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Summary: | The introduction of beta -lactamase inhibitors (clavulanate, sulbactam, or tazobactam) in association with beta-lactam antibiotics is one of the current strategies to overcome bacterial resistance. Unfortunately, beta -lactamases are also "inhibitors" of these new compounds. In Escherichia coli the frequency of amoxicillin-clavulanate-resistant strains (MIC equal to or more than 16/8 mu g/ml) is around 20 to 30% of that of amoxicillin-resistant isolates in certain Madrid hospitals. The authors previously reported that bacterial resistance to amoxicillin-clavulanate in clinical strains of E. coli can result from hyperproduction of plasmid-determined TEM-1 beta -lactamase. The same conclusion was reached about an amoxicillin-clavulanate-resistant E. coli strain from England. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
ISSN: | 0066-4804 1098-6596 |
DOI: | 10.1128/AAC.33.4.595-a |