Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure

The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R1, R3, R4, and R6) on the catenane scaffold, or the simultaneous switching of any com...

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Published inNano letters Vol. 15; no. 10; pp. 7133 - 7137
Main Authors Lu, Chun-Hua, Cecconello, Alessandro, Qi, Xiu-Juan, Wu, Na, Jester, Stefan-Sven, Famulok, Michael, Matthies, Michael, Schmidt, Thorsten-Lars, Willner, Itamar
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 14.10.2015
Subjects
Anthracenes - chemistry
Deoxyribonucleic acid
DNA - chemistry
Dynamical systems
Dynamics
Fluorescence
Isomerism
Isomers
Nanostructure
Nanostructures
Reconfiguration
Strands
fluorescence
machine
strand displacement
Nanobiotechnology
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Summary:The synthesis, purification, and structure characterization of a seven-ring interlocked DNA catenane is described. The design of the seven-ring catenane allows the dynamic reconfiguration of any of the four rings (R1, R3, R4, and R6) on the catenane scaffold, or the simultaneous switching of any combination of two, three, or all four rings to yield 16 different isomeric states of the catenane. The dynamic reconfiguration across the states is achieved by implementing the strand-displacement process in the presence of appropriate fuel/antifuel strands and is probed by fluorescence spectroscopy. Each of the 16 isomers of the catenane can be transformed into any of the other isomers, thus allowing for 240 dynamic transitions within the system.
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ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.5b03280