Multivariate Analysis of Risk Factors for Neck Metastases in Surgically Treated Parotid Carcinomas

• Published in: Archives of otolaryngology--head & neck surgery Vol. 127; no. 1; pp. 56 - 60
• Main Authors: Régis de Brito Santos, Izandro, Kowalski, Luiz P, Cavalcante de Araujo, Vera, Flávia Logullo, Angela, Magrin, José
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.01.2001
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - radiotherapy; Adenocarcinoma - surgery; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Biological and medical sciences; Carcinoma, Mucoepidermoid - pathology; Carcinoma, Mucoepidermoid - radiotherapy; Carcinoma, Mucoepidermoid - surgery; Child; Child, Preschool; Female; Follow-Up Studies; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - secondary; Head and Neck Neoplasms - surgery; Humans; Infant; Male; Medical sciences; Middle Aged; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Parotid Neoplasms - pathology; Parotid Neoplasms - radiotherapy; Parotid Neoplasms - surgery; Risk Factors; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Human; Carcinoma; Prognosis; Parotid gland; Stomatology; Parotidectomy; Malignant tumor; Metastasis; Multivariate analysis; Salivary gland disease; Surgery; Cohort study; Risk factor; ENT disease; Neck
• ISSN: 0886-4470; 2168-6181; 1538-361X; 2168-619X
• DOI: 10.1001/archotol.127.1.56

OBJECTIVE To analyze risk factors for neck metastases in patients with parotid carcinomas. DESIGN Cohort of patients followed up from 1 to 366.2 months at a single institution. SETTING Referral center, private or institutional practice, hospitalized care. PATIENTS A total of 145 patients with parotid carcinomas with complete clinical and pathological information. The histological diagnosis was reviewed according to the World Health Organization classification for salivary gland tumors. INTERVENTION Patients were treated by surgery alone (62 cases) or with postoperative radiotherapy (83 cases). A neck dissection was performed in 80 patients. MAIN OUTCOME MEASURE Rates of neck lymph node metastasis. Univariate and multivariate analyses were carried out using logistic regression evaluating the significance of demographic, clinical, and pathological data. RESULTS The following variables were significantly associated to the risk of lymph node metastasis by univariate analysis: histological type (P<.001), T stage (P<.001), desmoplasia (P = .001), facial palsy (P = .02), perineural invasion (P = .01), extraparotid tumor extension (P = .02), and necrosis (P = .003). By multivariate analysis, histological type (P<.001), T stage (P = .03), and desmoplasia (P = .006) had the highest correlation with lymph node metastasis. CONCLUSION The significant risk factors for neck metastasis in parotid carcinoma were histological type (ie, adenocarcinoma, undifferentiated carcinoma, high-grade mucoepidermoid carcinoma, squamous cell carcinoma, and salivary duct carcinoma), T stage (T3 and T4), and desmoplasia (severe).Arch Otolaryngol Head Neck Surg. 2001;127:56-60-->