Familial prevalence and coaggregation of schizotypy indicators: a multitrait family study

Schizophrenic probands (n = 17), their first-degree relatives (n = 61), and medically and psychiatrically screened normal control subjects (n = 18) were studied with structured interviews for DSM-III Axis I disorders and schizotypal personality disorder, questionnaire measures of schizotypy, measure...

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Bibliographic Details
Published inJournal of abnormal psychology (1965) Vol. 100; no. 2; p. 115
Main Authors Grove, W M, Lebow, B S, Clementz, B A, Cerri, A, Medus, C, Iacono, W G
Format Journal Article
LanguageEnglish
Published United States 01.05.1991
Subjects
Adult
Attention
Child
Eye Movements
Family - psychology
Female
Humans
Male
Middle Aged
MMPI
Phenotype
Psychiatric Status Rating Scales
Psychomotor Performance
Risk Factors
Schizophrenia - diagnosis
Schizophrenia - genetics
Schizophrenia - physiopathology
Schizotypal Personality Disorder - diagnosis
Schizotypal Personality Disorder - genetics
Schizotypal Personality Disorder - physiopathology
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Summary:Schizophrenic probands (n = 17), their first-degree relatives (n = 61), and medically and psychiatrically screened normal control subjects (n = 18) were studied with structured interviews for DSM-III Axis I disorders and schizotypal personality disorder, questionnaire measures of schizotypy, measures of smooth-pursuit eye movement dysfunction, and attention dysfunction. Schizophrenic subjects scored abnormally on essentially all measures. Relatives differed significantly from control subjects on most measures. Correlational analyses indicate that many characteristics tested in these measures run together in families. The data are consistent with the hypothesis that a single vulnerability dimension or typology, presumably in part genetically transmitted, may account for phenotypically distinct abnormalities. These traits, taken together, may have joint usefulness for identifying persons with a predisposition to schizophrenia.
ISSN:0021-843X
DOI:10.1037/0021-843X.100.2.115