Hollow Silica Nanocontainers as Drug Delivery Vehicles

• Published in: Langmuir Vol. 24; no. 7; pp. 3417 - 3421
• Main Authors: Yang, Jaemoon, Lee, Jaewon, Kang, Jinyoung, Lee, Kwangyeol, Suh, Jin-Suck, Yoon, Ho-Geun, Huh, Yong-Min, Haam, Seungjoo
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.04.2008
• Subjects: Chemistry; Colloidal state and disperse state; Doxorubicin - administration & dosage; Drug Delivery Systems; Exact sciences and technology; Ferric Compounds; General and physical chemistry; Nanocapsules - chemistry; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Silicon Dioxide; Structure-Activity Relationship; Surface physical chemistry; Drug; Surface charge; Nanoparticle; Transition element compounds; Solubility; High temperature; Doxorubicin; Silica; Template; Hydrochloric acid; Amine; Cavity; Aqueous medium; Models; Release; Nanocrystal
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la701688t

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.