Pachastrissamine, a Cytotoxic Anhydrophytosphingosine from a Marine Sponge, Pachastrissa sp

• Published in: Journal of natural products (Washington, D.C.) Vol. 65; no. 10; pp. 1505 - 1506
• Main Authors: Kuroda, Ikuma, Musman, Musri, Ohtani, Ikuko I, Ichiba, Toshio, Tanaka, Junichi, Gravalos, Dolores Garcia, Higa, Tatsuo
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.10.2002; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: anhydrophytosphingosine; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Drug Screening Assays, Antitumor; General pharmacology; Humans; Life Sciences & Biomedicine; Marine; Medical sciences; Molecular Structure; natural products; Pachastrissa; Pachastrissamine; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Porifera - chemistry; Science & Technology; Spectrum Analysis - methods; Sphingosine - analogs & derivatives; Sphingosine - chemistry; Sphingosine - isolation & purification; Sphingosine - pharmacology; Tumor Cells, Cultured; BIOLOGICALLY-ACTIVE GLYCOSIDES; ASTEROIDEA; PHYTOSPHINGOSINE; DERIVATIVES; STEREOCHEMISTRY; Antineoplastic agent; Five membered ring; Aminoalcohol; Pharmacognosy; Furan derivatives; Animal origin; Oxygen heterocycle; Marine environment; Porifera; Absolute configuration; Isolation; Invertebrata; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np010659y

An anhydrophytosphingosine named pachastrissamine (3) has been isolated as a cytotoxic principle of a sponge, Pachastrissa sp., and the structure including the absolute configuration determined by spectroscopic and chemical analysis.