Exploiting the Twisted Intramolecular Charge Transfer Effect to Construct a Wash-Free Solvatochromic Fluorescent Lipid Droplet Probe for Fatty Liver Disease Diagnosis

• Published in: Analytical chemistry (Washington) Vol. 94; no. 9; pp. 3881 - 3887
• Main Authors: Wu, Cheng-Juan, Li, Xin-Yu, Zhu, Ting, Zhao, Mengying, Song, Zhuoyue, Li, Shijie, Shan, Guo-Gang, Niu, Guangle
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.03.2022
• Subjects: Accumulation; analytical chemistry; Animal models; Animals; Charge transfer; Chemistry; Diagnosis; disease diagnosis; disease models; Droplets; Emissions; Fatty liver; Fatty Liver - diagnostic imaging; fluorescence; Fluorescent Dyes; Fluorescent indicators; Hepatocytes; Lipid Droplets; Lipids; Lipophilic; lipophilicity; Liver; Liver diseases; Medical imaging; Mice; Microscopy, Fluorescence; Permeability; photostability; Polar environments

The prominent pathological feature of fatty liver disease lesions is excessive fat accumulation in lipid droplets in hepatocytes. Thus, developing fluorescent lipid droplet-specific probes with high permeability and a high imaging contrast provides a robust tool for diagnosing fatty liver diseases....