The Synthesis and Chelation Chemistry of DOTA−Peptide Conjugates

Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)−peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesi...

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Bibliographic Details
Published inBioconjugate chemistry Vol. 19; no. 2; pp. 391 - 402
Main Authors De León-Rodríguez, Luis M, Kovacs, Zoltan
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.02.2008
Subjects
Acids
Chelating Agents - chemistry
Chemical synthesis
Heterocyclic Compounds, 1-Ring - chemistry
Metals
NMR
Nuclear magnetic resonance
Peptides
Peptides - chemistry
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Summary:Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)−peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA−peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA−peptide conjugate metal complexes.
Bibliography:ark:/67375/TPS-R6RMP601-D
istex:C4ECEC8D69EF1CB6A6E676E96A081B85DD1C895E
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-1802
1520-4812
DOI:10.1021/bc700328s