Absorption of Chlorogenic Acid and Caffeic Acid in Rats after Oral Administration

• Published in: Journal of agricultural and food chemistry Vol. 48; no. 11; pp. 5496 - 5500
• Main Authors: Azuma, Keiko, Ippoushi, Katsunari, Nakayama, Masayoshi, Ito, Hidekazu, Higashio, Hisao, Terao, Junji
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.11.2000
• Subjects: administration & dosage; Administration, Oral; Animals; Antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacokinetics; Biological and medical sciences; Biotransformation; blood; caffeic acid; Caffeic Acids; Caffeic Acids - administration & dosage; Caffeic Acids - blood; Caffeic Acids - pharmacokinetics; Chlorogenic Acid; Chlorogenic Acid - administration & dosage; Chlorogenic Acid - blood; Chlorogenic Acid - pharmacokinetics; General pharmacology; Glucuronides; Glucuronides - blood; Intestinal Absorption; Male; Medical sciences; oral administration; pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Rats; Rats, Wistar; small intestine; Sulfuric Acid Esters; Sulfuric Acid Esters - blood; Rat; Metabolite; Rodentia; Oral administration; Chlorogenic acid; Antioxidant; Radical scavenger; Biological activity; Caffeic acid; Blood; Vertebrata; Mammalia; Absorption; Phenols; Laboratory animal; Pharmacokinetics; Digestive tract

Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 μmol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h...