Absorption of Chlorogenic Acid and Caffeic Acid in Rats after Oral Administration

• Published in: Journal of agricultural and food chemistry Vol. 48; no. 11; pp. 5496 - 5500
• Main Authors: Azuma, Keiko, Ippoushi, Katsunari, Nakayama, Masayoshi, Ito, Hidekazu, Higashio, Hisao, Terao, Junji
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.11.2000
• Subjects: administration & dosage; Administration, Oral; Animals; Antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacokinetics; Biological and medical sciences; Biotransformation; blood; caffeic acid; Caffeic Acids; Caffeic Acids - administration & dosage; Caffeic Acids - blood; Caffeic Acids - pharmacokinetics; Chlorogenic Acid; Chlorogenic Acid - administration & dosage; Chlorogenic Acid - blood; Chlorogenic Acid - pharmacokinetics; General pharmacology; Glucuronides; Glucuronides - blood; Intestinal Absorption; Male; Medical sciences; oral administration; pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Rats; Rats, Wistar; small intestine; Sulfuric Acid Esters; Sulfuric Acid Esters - blood; Rat; Metabolite; Rodentia; Oral administration; Chlorogenic acid; Antioxidant; Radical scavenger; Biological activity; Caffeic acid; Blood; Vertebrata; Mammalia; Absorption; Phenols; Laboratory animal; Pharmacokinetics; Digestive tract
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf000483q

Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 μmol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms. Keywords: Absorption; chlorogenic acid; caffeic acid; rats; blood plasma; metabolites