Catechol-Functionalized Chitosan/Pluronic Hydrogels for Tissue Adhesives and Hemostatic Materials

• Published in: Biomacromolecules Vol. 12; no. 7; pp. 2653 - 2659
• Main Authors: Ryu, Ji Hyun, Lee, Yuhan, Kong, Won Ho, Kim, Taek Gyoung, Park, Tae Gwan, Lee, Haeshin
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 11.07.2011
• Subjects: Animals; Applied sciences; Biocompatible Materials; Biological and medical sciences; Catechols - administration & dosage; Catechols - chemistry; Chitosan - administration & dosage; Chitosan - chemistry; Cross-Linking Reagents - administration & dosage; Cross-Linking Reagents - chemical synthesis; Cross-Linking Reagents - chemistry; Exact sciences and technology; Hemostatics - administration & dosage; Hemostatics - chemical synthesis; Hemostatics - chemistry; Hydrogels - administration & dosage; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogen-Ion Concentration; Injections, Subcutaneous; Medical sciences; Mice; Mice, Inbred BALB C; Models, Animal; Molecular Structure; Natural polymers; Physicochemistry of polymers; Poloxamer - administration & dosage; Poloxamer - chemistry; Rats; Rats, Sprague-Dawley; Starch and polysaccharides; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Temperature; Tissue Adhesives - administration & dosage; Tissue Adhesives - chemical synthesis; Tissue Adhesives - chemistry; Biological properties; Viscoelasticity; Injectable form; Rat; Amidation; Colloidal gel; Surface properties; Biocompatibility; Biomaterial; Propylene oxide copolymer; Subcutaneous tissue; Erosion; Adhesivity; Gelation; Rodentia; Crosslinking; Ethylene oxide copolymer; Experimental study; Sulfur copolymer; In vitro; In vivo; Vertebrata; Triblock copolymer; Chemical modification; Mammalia; Chitosan derivatives; Animal; Preparation; Phenols; Oside polymer; Hemostatic adhesive; Chitosan; Kinetics
• ISSN: 1525-7797; 1526-4602
• DOI: 10.1021/bm200464x

Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive and adhesive sol–gel transition hydrogels. A blend mixture of the catechol-conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and antibleeding materials.