Crystal Structure of the Mobile Metallo-β-Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 8; pp. 4341 - 4353
• Main Authors: Leiros, Hanna-Kirsti S, Borra, Pardha S, Brandsdal, Bjørn Olav, Edvardsen, Kine Susann Waade, Spencer, James, Walsh, Timothy R, Samuelsen, Orjan
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.08.2012
• Subjects: Amino Acid Sequence; Anti-Bacterial Agents - metabolism; Antibiotics. Antiinfectious agents. Antiparasitic agents; beta-Lactamases; beta-Lactamases - chemistry; beta-Lactamases - genetics; beta-Lactamases - metabolism; beta-Lactams; beta-Lactams - metabolism; Binding Sites; Biological and medical sciences; Catalytic Domain; Crystallography, X-Ray; Mechanisms of Resistance; Medical sciences; Molecular Sequence Data; Mutagenesis, Site-Directed; Pharmacology. Drug treatments; Protein Folding; Protein Structure, Quaternary; Protein Structure, Tertiary; Pseudomonas aeruginosa; Pseudomonas aeruginosa - enzymology; Pseudomonas aeruginosa - metabolism; Sequence Alignment; Substrate Specificity; Pseudomonadales; Serine/threonine-protein kinase 12; Antibiotic; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Antibacterial agent; Crystalline structure
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00448-12

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