Two New Taxoids from the Stem Bark of Taxus baccata

• Published in: Journal of natural products (Washington, D.C.) Vol. 58; no. 12; pp. 1906 - 1912
• Main Authors: Guo, Yanwen, Diallo, Bilo, Jaziri, Mondher, Vanhaelen-Fastré, Renée, Vanhaelen, Maurice, Ottinger, Robert
• Format: Journal Article
• Language: English
• Published: CINCINNATI American Chemical Society 01.12.1995; AMER SOC PHARMACOGNOSY; American Society of Pharmacognosy
• Subjects: Animals; bark; Biological and medical sciences; Brain Chemistry - drug effects; chemical constituents of plants; chemical structure; Chemistry, Medicinal; diterpenoids; General pharmacology; Kinetics; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Microtubules - drug effects; Microtubules - metabolism; molecular conformation; Paclitaxel - analogs & derivatives; Paclitaxel - chemistry; Paclitaxel - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plant Stems - chemistry; Plants, Medicinal - chemistry; Science & Technology; spectral analysis; stems; Swine; Taxoids; Taxus cuspidata; Tubulin - biosynthesis; Belgium; Europe; Antineoplastic agent; Pharmacognosy; Bark; Tetracyclic compound; Tricyclic compound; Oxygen heterocycle; In vitro; Biological activity; Stem; Terpene; Gymnospermae; Plant origin; Diterpene; Taxus baccata; Isolation; Coniferales; Spermatophyta; Glycoside; Microtubule; Antimitotic; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50126a017

Two new taxoids, 13-deoxo-13 alpha-acetyloxy-7 beta,9 alpha-diacetyl-1,2-dideoxytaxine B [1] and 7 beta-xylosyl-10-deacetyltaxol D [7], were isolated from the stem bark of Taxus baccata cv. stricta. Their structures were elucidated using spectroscopic methods and their bioactivity was evaluated using an in vitro microtubule assembly assay.