Targeted Molecular Imaging Agents for Cellular-Scale Bimodal Imaging

Molecular imaging is a powerful tool that has the ability to elucidate biochemical mechanisms and signal the early onset of disease. Overexpression of the peripheral benzodiazepine receptor (PBR) has been observed in a variety disease states, including glioblastoma, breast cancer, and Alzheimer'...

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Published inBioconjugate chemistry Vol. 15; no. 6; pp. 1488 - 1495
Main Authors Manning, H. Charles, Goebel, Timothy, Thompson, Reid C, Price, Ronald R, Lee, Haakil, Bornhop, Darryl J
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.11.2004
Subjects
Animals
Brain
Cancer
Cell Line, Tumor
Cells
Chemistry
Drug Delivery Systems - methods
Medical imaging
Nuclear Magnetic Resonance, Biomolecular - methods
Rats
Receptors, GABA-A - analysis
Receptors, GABA-A - metabolism
Spectrometry, Fluorescence - methods
Xenopus laevis
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Summary:Molecular imaging is a powerful tool that has the ability to elucidate biochemical mechanisms and signal the early onset of disease. Overexpression of the peripheral benzodiazepine receptor (PBR) has been observed in a variety disease states, including glioblastoma, breast cancer, and Alzheimer's disease. Thus, the PBR could be an attractive target for molecular imaging. In this paper, the authors report cellular uptake and multimodal (MRI and fluorescence) imaging of PBR-overexpressing C6 glioblastoma (brain cancer) cells using a cocktail administration approach and a new PBR targeted lanthanide chelate molecular imaging agent.
Bibliography:istex:03A4F4E9402B2B6823968E9F0CC582F06C805C5D
ark:/67375/TPS-02ZTHM59-0
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ISSN:1043-1802
1520-4812
DOI:10.1021/bc049904q