Single- and Multiple-Ascending-Dose Studies of the NS3 Protease Inhibitor Asunaprevir in Subjects with or without Chronic Hepatitis C

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 4; pp. 1838 - 1844
• Main Authors: Pasquinelli, Claudio, McPhee, Fiona, Eley, Timothy, Villegas, Criselda, Sandy, Katrina, Sheridan, Pamela, Persson, Anna, Huang, Shu-Pang, Hernandez, Dennis, Sheaffer, Amy K., Scola, Paul, Marbury, Thomas, Lawitz, Eric, Goldwater, Ronald, Rodriguez-Torres, Maribel, DeMicco, Michael, Wright, David, Charlton, Michael, Kraft, Walter K., Lopez-Talavera, Juan-Carlos, Grasela, Dennis M.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2012
• Subjects: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Viral; Electrocardiography - drug effects; Female; Hepacivirus; Hepacivirus - drug effects; Hepacivirus - genetics; Hepatitis C, Chronic; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Human viral diseases; Humans; Infectious diseases; Isoquinolines; Isoquinolines - administration & dosage; Isoquinolines - adverse effects; Isoquinolines - therapeutic use; Male; Medical sciences; Pharmacology. Drug treatments; Replicon; RNA, Viral - drug effects; Sample Size; Sulfonamides; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Viral diseases; Viral hepatitis; Viral Nonstructural Proteins; Viral Nonstructural Proteins - antagonists & inhibitors; Infection; Multiple dose; Human; Viral disease; Digestive diseases; Hepatic disease; Antiviral; Protease inhibitor; Viral hepatitis C
• ISSN: 0066-4804; 1098-6596; 1098-6596
• DOI: 10.1128/AAC.05854-11

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