4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei

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Published inAntimicrobial Agents and Chemotherapy Vol. 57; no. 1; pp. 417 - 424
Main Authors LACRUE, Alexis N, SAENZ, Fabián E, CROSS, R. Matthew, UDENZE, Kenneth O, MONASTYRSKYI, Andrii, STEIN, Steven, MUTKA, Tina S, MANETSCH, Roman, KYLE, Dennis E
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.2013
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials
Antimalarials - chemical synthesis
Antimalarials - pharmacology
Biological and medical sciences
Female
Genes, Reporter
Hep G2 Cells
Hepatocytes - drug effects
Hepatocytes - parasitology
Humans
Inhibitory Concentration 50
Kinetics
Liver - drug effects
Liver - parasitology
Luciferases
Malaria
Malaria - drug therapy
Malaria - parasitology
Medical sciences
Mice
Mice, Inbred BALB C
Organisms, Genetically Modified
Pharmacology. Drug treatments
Plasmodium berghei
Plasmodium berghei - drug effects
Plasmodium berghei - genetics
Plasmodium berghei - growth & development
Quinolones
Quinolones - chemical synthesis
Quinolones - pharmacology
Sporozoites
Sporozoites - drug effects
Sporozoites - growth & development
Susceptibility
Protozoa
Apicomplexa
Plasmodium berghei
Clinical stage
Liver
Antibacterial agent
Biological activity
Quinolone derivatives
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
Bibliography:A.N.L. and F.S. contributed equally to this article.
Present address: Fabián Sáenz, Centro de Investigación en Enfermedades Infecciosas, Escuela de Ciencias Biológicas, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00793-12