Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

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Published inAntimicrobial Agents and Chemotherapy Vol. 52; no. 4; pp. 1291 - 1296
Main Authors Creek, Darren J, Charman, William N, Chiu, Francis C K, Prankerd, Richard J, Dong, Yuxiang, Vennerstrom, Jonathan L, Charman, Susan A
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.04.2008
American Society for Microbiology (ASM)
Subjects
Alkylation
Animals
Antimalarials
Antimalarials - chemical synthesis
Antimalarials - chemistry
Antimalarials - metabolism
Antimalarials - pharmacology
Artemisinins - pharmacology
Heme
Heme - metabolism
Humans
Kinetics
Mechanisms of Action: Physiological Effects
Parasitic Sensitivity Tests - methods
Plasmodium falciparum
Plasmodium falciparum - drug effects
Spiro Compounds
Spiro Compounds - chemical synthesis
Spiro Compounds - chemistry
Spiro Compounds - metabolism
Spiro Compounds - pharmacology
Structure-Activity Relationship
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Centre for Drug Candidate Optimisation, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Phone: 61 3 9903 9626. Fax: 61 3 9903 9560. E-mail: susan.charman@vcp.monash.edu.au
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01033-07