Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied l...

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Bibliographic Details
Published inACS infectious diseases Vol. 1; no. 11; p. 512
Main Authors Zgurskaya, Helen I, Löpez, Cesar A, Gnanakaran, S
Format Journal Article
LanguageEnglish
Published United States 01.01.2015
Subjects
outer membrane
multidrug efflux
permeability barrier
Gram-negative resistance
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Summary:Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This paper summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.
ISSN:2373-8227
2373-8227
DOI:10.1021/acsinfecdis.5b00097