Rapid Clinical Induction of Hepatic Cytochrome P4502B6 Activity by Ritonavir

• Published in: Antimicrobial Agents and Chemotherapy Vol. 52; no. 5; pp. 1663 - 1669
• Main Authors: KHARASCH, Evan D, MITCHELL, Darain, COLES, Rebecka, BLANCO, Roberto
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.2008; American Society for Microbiology (ASM)
• Subjects: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Hydroxylases - metabolism; Biological and medical sciences; Bupropion - analogs & derivatives; Bupropion - blood; Bupropion - urine; Cross-Over Studies; Cytochrome P-450 CYP2B6; Female; HIV Protease Inhibitors - pharmacokinetics; HIV Protease Inhibitors - pharmacology; Humans; Liver; Liver - drug effects; Liver - enzymology; Male; Medical sciences; Oxidoreductases, N-Demethylating; Oxidoreductases, N-Demethylating - metabolism; Pharmacology. Drug treatments; Ritonavir; Ritonavir - pharmacokinetics; Ritonavir - pharmacology; Cytochrome; Peptidases; Antiretroviral agent; Enzyme; Induction; Ritonavir; Liver; Enzyme inhibitor; Hydrolases; Antiviral; Protease inhibitor; Biological activity
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01600-07

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