Applications of Sol−Gel-Derived Membranes to Neutral Carrier-Type Ion-Sensitive Field-Effect Transistors

• Published in: Analytical chemistry (Washington) Vol. 69; no. 13; pp. 2379 - 2383
• Main Authors: Kimura, Keiichi, Sunagawa, Takenobu, Yokoyama, Masaaki
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.07.1997
• Subjects: Analytical chemistry; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Chemistry; Electrochemical methods; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; Inorganic compounds; Ions; Membranes; Other biological molecules; Response function; Biological fluid; Membrane electrode; Chemical analysis; Sol gel process; Crown compound; Carrier; Performance; Blood serum; Potassium; Ionosensible field effect transistor
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/ac9611069

Sol−gel-derived membranes encapsulating neutral carriers, such as valinomycin and a bis(crown ether) derivative, were fabricated as novel ion-sensing membranes for neutral carrier-type ion-sensitive field-effect transistors (ISFETs). The neutral carrier-type sol−gel-derived membranes obtained with an initial diethoxydimethylsilane/tetraethoxysilane ratio of 3 gave excellent results for membrane processibility and sensitivity, response time, and selectivity in the resulting ion sensors. The sol−gel-derived ion-sensing membranes containing neutral carriers are superior in the thrombogenic property to their corresponding plasticized poly(vinyl chloride) membranes. The potassium and sodium ISFETs thus obtained were successfully applied to the ion assay in blood sera.