Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

• Published in: ACS catalysis Vol. 3; no. 10; pp. 2362 - 2370
• Main Authors: Barry, Sarah M, Challis, Gregory L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.10.2013
• Subjects: C−H functionalization; dihydroxylation; biodegradation; amine oxidation; oxidative cyclisation; biosynthesis; Biodegradation; Oxidative Cyclisation; Biosynthesis; Dihydroxylation; C-H functionalization; Amine Oxidation

Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases a...