Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases a...

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Published inACS catalysis Vol. 3; no. 10; pp. 2362 - 2370
Main Authors Barry, Sarah M, Challis, Gregory L
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 04.10.2013
Subjects
C−H functionalization
dihydroxylation
biodegradation
amine oxidation
oxidative cyclisation
biosynthesis
Biodegradation
Oxidative Cyclisation
Biosynthesis
Dihydroxylation
C-H functionalization
Amine Oxidation
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Summary:Rieske non-heme iron-dependent oxygenases are important enzymes that catalyze a wide variety of reactions in the biodegradation of xenobiotics and biosynthesis of bioactive natural products. In this Perspective, we summarize recent efforts to elucidate the catalytic mechanisms of Rieske oxygenases and highlight the diverse range of reactions now known to be catalyzed by such enzymes.
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Current address Department of Chemistry, School of Biomedical Sciences, King’s College London, London SE1 1DB, UK
Tel. +44 (0) 2476 574024; Fax +44 (0) 2476 524112; g.l.challis@warwick.ac.uk
ISSN:2155-5435
2155-5435
DOI:10.1021/cs400087p