Pharmacodynamic modeling of the in vivo interaction between cefotaxime and ofloxacin by using serum ultrafiltrate inhibitory titers

• Published in: Antimicrobial Agents and Chemotherapy Vol. 41; no. 5; pp. 1108 - 1114
• Main Authors: NIX, D. E, WILTON, J. H, HYATT, J, THOMAS, J, STRENKOSKI-NIX, L. C, FORREST, A, SCHENTAG, J. J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.1997
• Subjects: Adult; Anti-Infective Agents; Anti-Infective Agents - blood; Anti-Infective Agents - pharmacokinetics; Anti-Infective Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Biological and medical sciences; Cefotaxime; Cefotaxime - adverse effects; Cefotaxime - blood; Cefotaxime - pharmacokinetics; Cefotaxime - pharmacology; Cephalosporins; Cephalosporins - adverse effects; Cephalosporins - blood; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Clinical Trial; Comparative Study; Cross-Over Studies; Drug Combinations; Drug Interactions; Female; Hemofiltration - methods; Humans; Male; Medical sciences; Microbial Sensitivity Tests; Models, Biological; Ofloxacin; Ofloxacin - adverse effects; Ofloxacin - blood; Ofloxacin - pharmacokinetics; Ofloxacin - pharmacology; Pharmacology. Drug treatments; Randomized Controlled Trial; Human; Drug combination; Cefotaxime; Metabolite; Prediction; Normal; Ofloxacin; In vitro; Modeling; Biological activity; In vivo; Antibiotic; Cephalosporin derivatives; Fluoroquinolone derivatives; Drug interaction; Antibacterial agent; Pharmacokinetics; Quinolone derivatives
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.41.5.1108

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