Pd(II)-Catalyzed Enantioselective C–H Activation/C–O Bond Formation: Synthesis of Chiral Benzofuranones

Pd(II)-catalyzed enantioselective C–H activation of phenylacetic acids followed by an intramolecular C–O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C–H functionalizations through Pd(II)/Pd(IV) redox catalysis.

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 135; no. 4; pp. 1236 - 1239
Main Authors Cheng, Xiu-Fen, Li, Yan, Su, Yi-Ming, Yin, Feng, Wang, Jian-Yong, Sheng, Jie, Vora, Harit U, Wang, Xi-Sheng, Yu, Jin-Quan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 30.01.2013
Amer Chemical Soc
Subjects
Benzofurans - chemical synthesis
Benzofurans - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Models, Molecular
Molecular Structure
Organometallic Compounds - chemistry
Palladium - chemistry
Physical Sciences
Science & Technology
Stereoisomerism
FUNCTIONALIZATION
DIBENZOFURANS
PALLADIUM
BENZOFURAN-2(3H)-ONES
AMINATION
ACIDS
NATURAL-PRODUCTS
COPPER
C(SP)-H
CYCLIZATION
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Summary:Pd(II)-catalyzed enantioselective C–H activation of phenylacetic acids followed by an intramolecular C–O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C–H functionalizations through Pd(II)/Pd(IV) redox catalysis.
Bibliography:NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Author Contributions
X.-F. C. and Y. L. contributed equally.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja311259x