Characterization of human tibrovirus envelope glycoproteins

Human tibroviruses are poorly characterized emerging rhabdoviruses associated with either asymptomatic infection or severe disease with a case fatality rate as high as 60% in humans. However, the extent and burden of human infection as well as factors behind differences in infection outcomes are lar...

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Published inJournal of Virology Vol. 98; no. 7; p. e0049924
Main Authors Munyeku-Bazitama, Yannick, Saito, Takeshi, Hattori, Takanari, Miyamoto, Hiroko, Lombe, Boniface Pongombo, Mori-Kajihara, Akina, Kajihara, Masahiro, Muyembe-Tamfum, Jean-Jacques, Igarashi, Manabu, Park, Eun-sil, Morikawa, Shigeru, Makiala-Mandanda, Sheila, Takada, Ayato
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 23.07.2024
Subjects
Amino Acid Sequence
Animals
Antibodies, Viral - immunology
Cell Line
Glycosylation
HEK293 Cells
Humans
Mice
Mucin-1 - metabolism
Viral Envelope Proteins - genetics
Viral Envelope Proteins - metabolism
Viral Tropism
Virology
Virus Internalization
Virus-Cell Interactions
Ekpoma virus 2
Ekpoma virus 1
glycoprotein
Mundri virus
Bas-Congo virus
Tibrogargan virus
tibrovirus
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Summary:Human tibroviruses are poorly characterized emerging rhabdoviruses associated with either asymptomatic infection or severe disease with a case fatality rate as high as 60% in humans. However, the extent and burden of human infection as well as factors behind differences in infection outcomes are largely unknown. In this study, we characterized human tibrovirus glycoproteins, which play a key role in virus-host interactions, mainly focusing on their structural and antigenic differences and cellular tropism. Our results provide critical information for understanding the biological properties of these novel viruses and for developing appropriate preparedness interventions such as diagnostic tools, vaccines, and effective therapies.
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Present address: Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
The authors declare no conflict of interest.
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/jvi.00499-24