Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia platycarpa

• Published in: Journal of natural products (Washington, D.C.) Vol. 69; no. 12; pp. 1687 - 1691
• Main Authors: Narváez-Mastache, José M, Garduño-Ramírez, María Luisa, Alvarez, Laura, Delgado, Guillermo
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.12.2006; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: animal disease models; Animals; Biological and medical sciences; blood glucose; Blood Glucose - drug effects; chemical constituents of plants; chemical structure; Chemistry, Medicinal; diabetes mellitus; dimethylchroman flavone; Eysenhardtia platycarpa; Fabaceae; Fabaceae - chemistry; flavones; Flavones - chemistry; Flavones - isolation & purification; Flavones - pharmacology; flavonoids; General pharmacology; glycemic effect; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - isolation & purification; Hypoglycemic Agents - pharmacology; Life Sciences & Biomedicine; Male; Medical sciences; medicinal plants; Mexico; Models, Animal; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; plant extracts; Plant Leaves - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Rats; Rats, Wistar; Science & Technology; spectral analysis; Streptozocin - pharmacology; traditional medicine; Mexico; Central America; America; ALPHA-HYDROXYDIHYDROCHALCONES; FLAVANONES; ACID; GLUCOSE; CHEMISTRY; POLYSTACHYA; FLAVONOIDS; TRITERPENES; HEALTHY; MEDICINAL-PLANTS; Endocrinopathy; Rat; Oxygen heterocycle; Flavonoid; Medicinal plant; Hypoglycemic agent; Folk medicine; Dicotyledones; Angiospermae; Bicyclic compound; Aromatic compound; Pharmacognosy; Diabetes mellitus; Rodentia; Plant leaf; Tricyclic compound; Biological activity; Flavanone derivatives; Oleanane derivatives; Intragastric administration; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Treatment; Leguminosae; Animal; Plant origin; Flavone derivatives; Phenols; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np060166z

The methanolic extracts from branches (BEP) and leaves (LEP) of Eysenhardtia platycarpa significantly decreased the blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats. One new flavone, (1‘ ‘R)-5,4‘,1‘ ‘-trihydroxy-6,7-(3‘ ‘,3‘ ‘-dimethylchroman)flavone (1), together with the known compounds 5,7-dihydroxy-6-methyl-8-prenylflavanone (3), 5,7-dihydroxy-8-methyl-6-prenylflavanone (4), 5,7-dihydroxy-6-prenylflavanone (5), 5,7-dihydroxy-8-prenylflavanone (6), 3-O-acetyloleanolic acid (7), oleanolic acid, 3β-acetoxy-11α,12α-epoxy-oleanan-28,13β-olide, lupeol, betulinic acid, β-sitosterol, β-sitosteryl β-d-glucopyranoside, β-sitosteryl palmitate, and 3-O-methyl-myo-inositol were isolated from BEP. Additionally, one new flavanone, (2S)-4‘-O-methyl-6-methyl-8-prenylnaringenin (2), as well as the known compounds 3, 4, 6, 4‘-O-methyl-8-prenylnaringenin (8), and 5-hydroxy-7-methoxy-8-prenylflavanone (9) were isolated from LEP. 3-O-Acetyloleanolic acid (7), identified as the major constituent of BEP, showed a significant decrease (31 mg/kg of body weight, P < 0.05) in the glucose level of STZ-induced diabetic rats. The obtained results correlate with the traditional use of this species.