Antineoplastic Agents, 301. An Investigation of the Amaryllidaceae Genus Hymenocallis

Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection, were investigated as sources of pancratistatin [1] now undergoing preclinical development as an anticancer agent. Pancratistatin [1] was found...

Full description

Saved in:
Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 58; no. 5; pp. 756 - 759
Main Authors Pettit, George R, Groszek, Grazyna, Backhaus, Ralph A, Doubek, Dennis L, Barr, Roland J, Meerow, Alan W
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.05.1995
Subjects
AGENTES ANTINEOPLASTICOS
Amaryllidaceae Alkaloids
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
BERMUDA
BERMUDAS
BERMUDES
CHEMICAL COMPOSITION
Chromatography, Ion Exchange
Chromatography, Thin Layer
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DRUG PLANTS
HYMENOCALLIS
hymenocallis pedalis
hymenocallis sonoranensis
HYMENOCALLIS SPECIOSA
hymenocallus expansa
Isoquinolines - chemistry
Isoquinolines - isolation & purification
Isoquinolines - pharmacology
ISRAEL
MEDICAMENT CYTOSTATIQUE
MEDICINAL PLANTS
MEXICO
MEXIQUE
MOLECULAR CONFORMATION
molecular structure
pancratistatin
PANCRATIUM
pancratium maritimum
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
SEYCHELLES
SINGAPORE
SINGAPOUR
SINGAPUR
Online AccessGet full text

Cover

More Information
Summary:Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection, were investigated as sources of pancratistatin [1] now undergoing preclinical development as an anticancer agent. Pancratistatin [1] was found to be a constituent of H. speciosa (Singapore), H. variegated (Singapore), H. pedalis (Seychelles), H. expansa (Bermuda), H. sonoranensis (Mexico), and P. maritimum (Israel). Only two species of Hymenocallis failed to yield one or more of the related cell-growth inhibitory isocarbostyrils such as narciclasine [3a], 7-deoxynarciclasine [3b], and 7-deoxy-trans-dihydronarciclasine [2].
Bibliography:F60
Q60
9556653
istex:7D487914B92FF15886DF46E541D3529E0604BA2D
ark:/67375/TPS-D4X924S3-5
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0163-3864
1520-6025
DOI:10.1021/np50119a017