Bioactive Constituents from Asparagus cochinchinensis

• Published in: Journal of natural products (Washington, D.C.) Vol. 67; no. 2; pp. 194 - 200
• Main Authors: Zhang, Hong-Jie, Sydara, Kongmany, Tan, Ghee Teng, Ma, Cuiying, Southavong, Bounhoong, Soejarto, D. Doel, Pezzuto, John M, Fong, Harry H. S
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.02.2004; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Acetylation; Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - isolation & purification; Angiogenesis Inhibitors - pharmacology; Anti-HIV Agents - chemistry; Anti-HIV Agents - isolation & purification; Anti-HIV Agents - pharmacology; Asparagus Plant - chemistry; Biological and medical sciences; Chemistry, Medicinal; General pharmacology; Humans; Inhibitory Concentration 50; KB Cells; Laos; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Science & Technology; Spirostans - chemistry; Spirostans - isolation & purification; Spirostans - pharmacology; Asia; China; Laos; SAPOGENINS; YUCCA; STEROIDAL SAPONINS; NMR SPECTRAL INVESTIGATIONS; MEDICINAL-PLANTS; RADIX; Antineoplastic agent; Steroid; Monocotyledones; Acetylenic compound; Alcohol; Cytotoxicity; Medicinal plant; Saponin; Polyphenol; Angiospermae; Antiviral; Glycoside; Human; Root; Pharmacognosy; Retroviridae; Lentivirus; In vitro; Biological activity; Virus; Liliaceae; Cell line; Plant origin; Phenols; Isolation; Spermatophyta; Umbilical cord; Human immunodeficiency virus; Prostate; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np030370b

Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3‘ ‘-methoxyasparenydiol (4), and a new polyphenol, 3‘-hydroxy-4‘-methoxy-4‘-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3‘ ‘-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC50 values ranging from 4 to 12 μg/mL. The structures were determined by spectroscopic and chemical methods.