Gummiferol, a Cytotoxic Polyacetylene from the Leaves of Adenia gummifera

• Published in: Journal of natural products (Washington, D.C.) Vol. 58; no. 10; pp. 1625 - 1628
• Main Authors: Fullas, Fekadu, Brown, Daniel M, Wani, Mansukh C, Wall, Monroe R, Chagwedera, Tangai E, Farnsworth, Norman R, Pezzuto, John M, Kinghorn, A. Douglas
• Format: Journal Article
• Language: English
• Published: CINCINNATI American Chemical Society 01.10.1995; AMER SOC PHARMACOGNOSY; American Society of Pharmacognosy
• Subjects: Acetates - chemistry; Acetates - isolation & purification; Acetates - pharmacology; AGENTES ANTINEOPLASTICOS; ANTINEOPLASTIC AGENTS; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; CHEMICAL COMPOSITION; Chemistry, Medicinal; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; CYTOTOXIC COMPOUNDS; ESPECTROMETRIA; Fatty Alcohols - chemistry; Fatty Alcohols - isolation & purification; Fatty Alcohols - pharmacology; FEUILLE; General pharmacology; HIDROCARBUROS; HOJAS; HUMAN CANCER CELL LINES; Humans; HYDROCARBONS; HYDROCARBURE; KB HUMAN CELL LINES; LEAVES; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; MEDICAMENT CYTOSTATIQUE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEOPLASMAS; NEOPLASME; NEOPLASMS; PASSIFLORACEAE; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plant Sciences; Science & Technology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; SUBSTANCE TOXIQUE; SUSTANCIAS TOXICAS; TOXIC SUBSTANCES; Tumor Cells, Cultured; ZIMBABWE; Africa; HETERONUCLEAR; SENSITIVITY-ENHANCED DETECTION; Antineoplastic agent; Diepoxide; Passifloraceae; Aliphatic compound; Pharmacognosy; Cytotoxicity; Foil; In vitro; Biological activity; Medicinal plant; Polyynic compound; Dicotyledones; Angiospermae; Established cell line; Plant origin; Isolation; Spermatophyta; Tumor cell; Ethylenic compound; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50124a027

A new polyacetylenic diepoxide compound, gummiferol [1] was isolated from the leaves of Adenia gummifera by KB cytotoxicity-guided fractionation. Compound 1 exhibited significant activity against the KB human cell line and a broad cytotoxic spectrum against other human cancer cell lines. The structure of 1 was established primarily on the basis of its spectral data.