Stereochemistry of the Roridins. Diastereomers of Roridin E
A careful investigation of cultures of Myrothecium verrucaria has shown that this fungus produces all four roridin E isomers (3a−d), diastereomeric at the C-6‘ and C-13‘ centers. The stereochemistries at these centers were established by a combination of X-ray crystallographic analysis, NMR spectros...
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Published in | Journal of natural products (Washington, D.C.) Vol. 62; no. 9; pp. 1284 - 1289 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.09.1999
Amer Chemical Soc American Society of Pharmacognosy |
Subjects | |
Online Access | Get full text |
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Summary: | A careful investigation of cultures of Myrothecium verrucaria has shown that this fungus produces all four roridin E isomers (3a−d), diastereomeric at the C-6‘ and C-13‘ centers. The stereochemistries at these centers were established by a combination of X-ray crystallographic analysis, NMR spectroscopy, and chemical transformations. NMR data from these and other macrocyclic trichothecenes allows for the assignment of configurations at the C-6‘ and C-13‘ centers for most of these compounds, the exceptions being those congeners having a C-4‘ ketone group in the macrolide ring. |
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Bibliography: | ark:/67375/TPS-3R6Z05BJ-8 istex:DB95C70EB39BFCEB4785F4C5F9C3A564A991EA86 Medline NIH RePORTER |
ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np990272j |