Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating...

Full description

Saved in:

Bibliographic Details
Published in	Nano letters Vol. 12; no. 6; pp. 3050 - 3061
Main Authors	Wang, Xiang, Xia, Tian, Duch, Matthew C, Ji, Zhaoxia, Zhang, Haiyuan, Li, Ruibin, Sun, Bingbing, Lin, Sijie, Meng, Huan, Liao, Yu-Pei, Wang, Meiying, Song, Tze-Bin, Yang, Yang, Hersam, Mark C, Nel, André E
Format	Journal Article
Language	English
Published	Washington, DC American Chemical Society 13.06.2012
Subjects	Administration, Inhalation Animals Cellular Coated Materials, Biocompatible - chemistry Coating Cross-disciplinary physics: materials science; rheology Exact sciences and technology Fibrosis Injury prevention Lysosomes - drug effects Lysosomes - pathology Materials science Mice Multi wall carbon nanotubes Nanocrystalline materials Nanoscale materials and structures: fabrication and characterization Nanostructure Nanotubes Nanotubes, Carbon - toxicity Physics Poloxamer - chemistry Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Serum albumin Surgical implants Tubes biocompatible pluronic copolymer dispersion lung fibrosis Multiwalled carbon nanotubes (MWCNTs) In vivo Multiwalled nanotube Carbon nanotubes Serum albumin Damage Coatings Nanostructured materials
Online Access	Get full text

Cover

Loading…

Abstract	We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.
AbstractList	We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs. We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs. We compared the use of bovine serum albumin (BSA) and Pluronic F108 (PF108) as dispersants for multi-walled carbon nanotubes (MWCNTs) in terms of tube stability as well as pro-fibrogenic effects in vitro and in vivo . While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could be served as a safer design approach for MWCNTs.
Author	Hersam, Mark C Sun, Bingbing Liao, Yu-Pei Wang, Meiying Meng, Huan Song, Tze-Bin Nel, André E Yang, Yang Wang, Xiang Duch, Matthew C Ji, Zhaoxia Xia, Tian Li, Ruibin Lin, Sijie Zhang, Haiyuan
AuthorAffiliation	Northwestern University University of California
AuthorAffiliation_xml	– name: University of California – name: Northwestern University – name: Division of NanoMedicine, Department of Medicine, Northwestern University, Evanston, Illinois 60208, United States – name: Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, United States – name: ζ Departments of Materials Science and Engineering, Chemistry, and Medicine, Northwestern University, Evanston, Illinois 60208, United States – name: California NanoSystems Institute, Northwestern University, Evanston, Illinois 60208, United States
Author_xml	– sequence: 1 givenname: Xiang surname: Wang fullname: Wang, Xiang – sequence: 2 givenname: Tian surname: Xia fullname: Xia, Tian – sequence: 3 givenname: Matthew C surname: Duch fullname: Duch, Matthew C – sequence: 4 givenname: Zhaoxia surname: Ji fullname: Ji, Zhaoxia – sequence: 5 givenname: Haiyuan surname: Zhang fullname: Zhang, Haiyuan – sequence: 6 givenname: Ruibin surname: Li fullname: Li, Ruibin – sequence: 7 givenname: Bingbing surname: Sun fullname: Sun, Bingbing – sequence: 8 givenname: Sijie surname: Lin fullname: Lin, Sijie – sequence: 9 givenname: Huan surname: Meng fullname: Meng, Huan – sequence: 10 givenname: Yu-Pei surname: Liao fullname: Liao, Yu-Pei – sequence: 11 givenname: Meiying surname: Wang fullname: Wang, Meiying – sequence: 12 givenname: Tze-Bin surname: Song fullname: Song, Tze-Bin – sequence: 13 givenname: Yang surname: Yang fullname: Yang, Yang – sequence: 14 givenname: Mark C surname: Hersam fullname: Hersam, Mark C – sequence: 15 givenname: André E surname: Nel fullname: Nel, André E email: anel@mednet.ucla.edu
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25989694$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22546002$$D View this record in MEDLINE/PubMed
BookMark	eNqFkkuPFCEUhYkZ4zx04R8wbEx00c6FgqpiY2JaWydpdWJ0XaHoywwdGkaoGlP_XirTto9M4goC3zmcm8MpOQoxICFPGbxiwNl58BVAq-T0gJwwWcGiVoofHfatOCanOW8BQFUSHpFjzqWoAfgJub30Y4rBGbpi0NJl1IMLV_QtmoQ6Y6bDNdL1WI5Wrk8xu0wv44BhcNrTaOnH0Q_uh_aeLnXqY6CfdIjD2BdlP9EvuBnN7LeecsxxVzQXYTum6TF5aLXP-GS_npFvq3dflx8W68_vL5Zv1gst6nZY6AoUbqxA4G3NW4CqUdZUjbW4MbKxQtpa960VdYOisRuUwmqOXEqOZXiszsjrO9-bsd8VTQmetO9uktvpNHVRu-7vm-Cuu6t42wkmKqbaYvBib5Di9xHz0O1cNui9DhjH3LGm5iBBKvV_FGZS1dXs-uzPWIc8v3opwPM9oLPR3iYdjMu_OalaVStRuJd3nCnd5IT2gDCYH2Td4W8U9vwf1rih1B3nyZ2_V7FPoU3utnFMoXR1D_cTPRXIdw
CitedBy_id	crossref_primary_10_1089_aivt_2017_0033 crossref_primary_10_1039_C8RA03898H crossref_primary_10_1039_C6TB01131D crossref_primary_10_1111_jphp_12434 crossref_primary_10_1093_nsr_nww064 crossref_primary_10_1007_s11434_014_0700_0 crossref_primary_10_1016_j_ecoenv_2018_09_077 crossref_primary_10_3389_ftox_2022_836447 crossref_primary_10_3390_ijms24129824 crossref_primary_10_1021_nn406166n crossref_primary_10_1080_1061186X_2024_2316785 crossref_primary_10_1016_j_actbio_2025_02_065 crossref_primary_10_1002_smll_202000603 crossref_primary_10_1021_acsnano_6b01560 crossref_primary_10_1016_j_cej_2022_135629 crossref_primary_10_1016_j_carbon_2015_11_060 crossref_primary_10_1016_j_biomaterials_2014_04_067 crossref_primary_10_1016_j_ejphar_2020_173090 crossref_primary_10_1021_nn404211j crossref_primary_10_3390_molecules26123610 crossref_primary_10_1016_j_taap_2018_10_023 crossref_primary_10_1021_nn305567s crossref_primary_10_1021_acsami_6b12768 crossref_primary_10_1016_j_biomaterials_2019_03_034 crossref_primary_10_1016_j_biomaterials_2016_11_005 crossref_primary_10_1007_s11434_016_1069_z crossref_primary_10_1016_j_addr_2013_05_012 crossref_primary_10_1002_smll_201901642 crossref_primary_10_3109_17435390_2015_1088588 crossref_primary_10_1021_acsnano_8b08517 crossref_primary_10_1021_acsnano_6b07895 crossref_primary_10_1371_journal_pone_0065756 crossref_primary_10_1002_smll_201301597 crossref_primary_10_1517_17425247_2015_1003806 crossref_primary_10_1016_j_nantod_2021_101151 crossref_primary_10_1021_acsnano_6b04143 crossref_primary_10_1007_s00204_016_1742_7 crossref_primary_10_1016_j_copbio_2013_11_008 crossref_primary_10_1021_acsnano_6b06040 crossref_primary_10_1002_smll_201700776 crossref_primary_10_1016_j_addr_2013_07_019 crossref_primary_10_1039_C5BM00134J crossref_primary_10_1039_C6EN00009F crossref_primary_10_1016_j_impact_2016_08_002 crossref_primary_10_2217_nnm_14_42 crossref_primary_10_2139_ssrn_4047253 crossref_primary_10_1002_smll_201402859 crossref_primary_10_1021_acs_chemrestox_0c00051 crossref_primary_10_1021_acsnano_8b01086 crossref_primary_10_1016_j_jhazmat_2018_04_025 crossref_primary_10_1186_s12989_017_0193_5 crossref_primary_10_1002_smll_201202128 crossref_primary_10_2217_nnm_13_213 crossref_primary_10_1007_s00216_018_1289_y crossref_primary_10_1007_s11356_023_25431_9 crossref_primary_10_1016_j_jes_2021_04_021 crossref_primary_10_1007_s11051_018_4221_7 crossref_primary_10_1186_s11671_018_2589_z crossref_primary_10_3109_17435390_2016_1163743 crossref_primary_10_1021_acs_est_6b01536 crossref_primary_10_1186_s12989_016_0123_y crossref_primary_10_1021_es502440s crossref_primary_10_1021_nn507243w crossref_primary_10_1002_smll_201603830 crossref_primary_10_1021_nn5012754 crossref_primary_10_1088_1742_6596_1567_4_042008 crossref_primary_10_1007_s12274_015_0791_1 crossref_primary_10_1039_C8NR04110E crossref_primary_10_1002_smll_201201962 crossref_primary_10_1021_acsami_7b05817 crossref_primary_10_1080_10717544_2016_1233592 crossref_primary_10_1002_chem_201900662 crossref_primary_10_1002_smll_201300607 crossref_primary_10_1021_acsnano_5b03443 crossref_primary_10_1016_j_cjprs_2022_01_001 crossref_primary_10_1186_1743_8977_10_52 crossref_primary_10_1007_s11051_024_05935_2 crossref_primary_10_1016_j_jhazmat_2021_125984 crossref_primary_10_1186_1556_276X_8_100 crossref_primary_10_1016_j_tox_2012_11_011 crossref_primary_10_1289_ehp_1206091 crossref_primary_10_1021_nn4037927 crossref_primary_10_1002_smll_201500906 crossref_primary_10_3109_17435390_2013_779757 crossref_primary_10_1016_j_taap_2016_01_022 crossref_primary_10_2174_1874325001610010877 crossref_primary_10_1016_j_jaci_2016_02_023 crossref_primary_10_1039_C8CP03576H crossref_primary_10_1016_j_desal_2016_06_019 crossref_primary_10_1016_j_eurpolymj_2023_112534 crossref_primary_10_3109_17435390_2015_1107147 crossref_primary_10_1111_joim_12109 crossref_primary_10_3389_fbioe_2020_00822 crossref_primary_10_1016_j_carbon_2018_02_058 crossref_primary_10_3390_ijms22010385 crossref_primary_10_1002_smll_202000528 crossref_primary_10_1016_j_taap_2017_04_019 crossref_primary_10_1002_smll_201703915 crossref_primary_10_1002_smll_201201700 crossref_primary_10_1016_j_isci_2022_104456 crossref_primary_10_1021_acsnano_6b03013 crossref_primary_10_1016_j_cossms_2022_101043 crossref_primary_10_1016_j_impact_2022_100380 crossref_primary_10_1021_ja304907c crossref_primary_10_1016_j_biomaterials_2016_08_036 crossref_primary_10_1080_15287394_2013_825571 crossref_primary_10_3390_nano12213908 crossref_primary_10_3390_molecules26195771 crossref_primary_10_1002_adma_201705691 crossref_primary_10_1039_C8EN00190A crossref_primary_10_1016_j_biomaterials_2014_12_008 crossref_primary_10_1039_C6NR06041B crossref_primary_10_1038_s41598_018_33414_x crossref_primary_10_1016_j_biomaterials_2021_120960 crossref_primary_10_1016_j_scib_2017_12_012 crossref_primary_10_1021_acsnano_5b00941 crossref_primary_10_1177_15330338231186388 crossref_primary_10_1016_j_envres_2014_09_025 crossref_primary_10_1021_tx5004003 crossref_primary_10_1038_srep04495 crossref_primary_10_1021_acs_nanolett_8b01805 crossref_primary_10_1111_jam_13010 crossref_primary_10_1016_j_ejpb_2016_04_015 crossref_primary_10_1038_srep24982 crossref_primary_10_1002_wnan_1498 crossref_primary_10_1038_jes_2017_6 crossref_primary_10_1155_2015_801606 crossref_primary_10_1038_s41428_018_0052_8 crossref_primary_10_1016_j_nantod_2022_101559 crossref_primary_10_1021_acs_molpharmaceut_9b00945 crossref_primary_10_1088_0957_4484_24_39_395602 crossref_primary_10_1007_s00253_018_9352_3 crossref_primary_10_1002_slct_201702951 crossref_primary_10_1021_acsami_6b12792 crossref_primary_10_2139_ssrn_4014167 crossref_primary_10_1073_pnas_1605030113 crossref_primary_10_1016_j_jes_2017_08_018
Cites_doi	10.1126/science.1114397 10.1186/1743-8977-2-8 10.1002/elps.200800737 10.1126/science.1156995 10.1021/ja046377c 10.1021/nn2033055 10.1186/1477-3155-9-45 10.1038/nri2725 10.1093/toxsci/kfg243 10.1021/nl9042483 10.1140/epjb/e2010-00093-6 10.1073/pnas.1105270108 10.1016/j.carbon.2011.01.003 10.1016/j.ajpath.2011.02.040 10.1080/15363830802515840 10.1289/ehp.0800319 10.1126/science.1060928 10.1165/ajrcmb/6.2.235 10.1093/toxsci/kfg228 10.1021/la103096n 10.1002/smll.201100437 10.3109/08958370903367359 10.1186/1755-1536-3-15 10.1021/nn102112b 10.1021/nn101151x 10.1016/j.cytogfr.2004.03.006 10.1080/08958370801942238 10.1021/nn200595c 10.1021/nn1028482 10.1021/es048729l 10.1021/nn101363m 10.1021/ja053003q 10.1016/j.tox.2009.10.017 10.1021/jz2003556 10.1038/nnano.2008.135 10.1021/tx800101p 10.1016/j.tiv.2005.06.031 10.1021/nn9011225 10.1021/nl202515a 10.1007/s12274-009-9009-8 10.1038/nnano.2009.305 10.1073/pnas.1110013108 10.1166/jnn.2009.025
ContentType	Journal Article
Copyright	Copyright © 2012 American Chemical Society 2015 INIST-CNRS
Copyright_xml	– notice: Copyright © 2012 American Chemical Society – notice: 2015 INIST-CNRS
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7SR 7U5 8BQ 8FD JG9 L7M 5PM
DOI	10.1021/nl300895y
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Engineered Materials Abstracts Solid State and Superconductivity Abstracts METADEX Technology Research Database Materials Research Database Advanced Technologies Database with Aerospace PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Materials Research Database Engineered Materials Abstracts Solid State and Superconductivity Abstracts Technology Research Database Advanced Technologies Database with Aerospace METADEX
DatabaseTitleList	MEDLINE Materials Research Database MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Engineering Physics
EISSN	1530-6992
EndPage	3061
ExternalDocumentID	PMC4143198 22546002 25989694 10_1021_nl300895y a875796086
Genre	Research Support, U.S. Gov't, Non-P.H.S Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIEHS NIH HHS grantid: U19 ES019528 – fundername: NIEHS NIH HHS grantid: R01 ES016746
GroupedDBID	- .K2 123 4.4 55A 5VS 7~N AABXI ABMVS ABPTK ABUCX ACGFS ACS AEESW AENEX AFEFF ALMA_UNASSIGNED_HOLDINGS AQSVZ BAANH CS3 DU5 EBS ED ED~ EJD F5P GNL IH9 IHE JG JG~ K2 LG6 PK8 RNS ROL TN5 UI2 VF5 VG9 W1F X --- -~X 6P2 AAHBH AAYXX ABBLG ABJNI ABLBI ABQRX ACBEA ADHLV AHGAQ CITATION CUPRZ GGK 53G AFFNX IQODW CGR CUY CVF ECM EIF NPM 7X8 7SR 7U5 8BQ 8FD JG9 L7M 5PM
ID	FETCH-LOGICAL-a468t-a309edf4e02862800379fc37ffedc57f45f6ab8f467e47fde54fa2e2552e153e3
IEDL.DBID	ACS
ISSN	1530-6984 1530-6992
IngestDate	Thu Aug 21 18:25:47 EDT 2025 Fri Jul 11 06:26:02 EDT 2025 Fri Jul 11 08:03:13 EDT 2025 Mon Jul 21 06:06:47 EDT 2025 Mon Jul 21 09:16:19 EDT 2025 Thu Apr 24 22:56:45 EDT 2025 Tue Jul 01 00:42:47 EDT 2025 Thu Aug 27 13:44:40 EDT 2020
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	6
Keywords	biocompatible pluronic copolymer dispersion lung fibrosis Multiwalled carbon nanotubes (MWCNTs) In vivo Multiwalled nanotube Carbon nanotubes Serum albumin Damage Coatings Nanostructured materials
Language	English
License	CC BY 4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-a468t-a309edf4e02862800379fc37ffedc57f45f6ab8f467e47fde54fa2e2552e153e3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributed equally to this work
OpenAccessLink	http://doi.org/10.1021/nl300895y
PMID	22546002
PQID	1020509638
PQPubID	23479
PageCount	12
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_4143198 proquest_miscellaneous_1762050599 proquest_miscellaneous_1020509638 pubmed_primary_22546002 pascalfrancis_primary_25989694 crossref_primary_10_1021_nl300895y crossref_citationtrail_10_1021_nl300895y acs_journals_10_1021_nl300895y
ProviderPackageCode	JG~ 55A AABXI GNL VF5 7~N VG9 W1F ACS AEESW AFEFF .K2 ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 CITATION AAYXX
PublicationCentury	2000
PublicationDate	2012-06-13
PublicationDateYYYYMMDD	2012-06-13
PublicationDate_xml	– month: 06 year: 2012 text: 2012-06-13 day: 13
PublicationDecade	2010
PublicationPlace	Washington, DC
PublicationPlace_xml	– name: Washington, DC – name: United States
PublicationTitle	Nano letters
PublicationTitleAlternate	Nano Lett
PublicationYear	2012
Publisher	American Chemical Society
Publisher_xml	– name: American Chemical Society
References	Bonner J. C. (ref22/cit22) 2004; 15 Duch M. C. (ref32/cit32) 2011; 11 Holt B. D. (ref37/cit37) 2011; 7 Stefaniak A. B. (ref40/cit40) 2006; 20 Li N. (ref48/cit48) 2009; 117 Hersam M. C. (ref4/cit4) 2008; 3 Lee J. H. (ref6/cit6) 2010; 22 Ciofani G. (ref30/cit30) 2009; 17 Murphy F. A. (ref19/cit19) 2011; 178 Nel A. (ref2/cit2) 2006; 311 Bonner J. C. (ref23/cit23) 2010; 3 Li R. B. (ref41/cit41) 2010; 4 Li R. B. (ref42/cit42) 2011; 49 Muller J. (ref5/cit5) 2008; 21 Donaldson K. (ref15/cit15) 2010 Warheit D. B. (ref17/cit17) 2004; 77 Jia G. (ref9/cit9) 2005; 39 Hamilton R. F. (ref36/cit36) 2009 Li R. B. (ref39/cit39) 2009; 30 Antaris A. L. (ref33/cit33) 2010; 4 Granite M. (ref29/cit29) 2011; 27 Oberdorster G. (ref7/cit7) 2005; 2 Nagai H. (ref14/cit14) 2011; 108 Shvedova A. A. (ref24/cit24) 2005; 289 Mercer R. R. (ref10/cit10) 2008; 294 Dostert C. (ref26/cit26) 2008; 320 Baughman R. H. (ref1/cit1) 2002; 297 Lam C. W. (ref16/cit16) 2004; 77 Wang X. (ref20/cit20) 2010; 4 Wang X. (ref21/cit21) 2011; 5 Ge C. C. (ref43/cit43) 2011; 108 Xia T. (ref47/cit47) 2011; 5 Ryman-Rasmussen J. P. (ref13/cit13) 2009; 4 Holt B. D. (ref44/cit44) 2010; 4 Palomaki J. (ref11/cit11) 2011; 5 Stone K. C. (ref46/cit46) 1992; 6 Mutlu G. M. (ref25/cit25) 2010; 10 Yaron P. N. H., B.D. (ref38/cit38) 2011; 9 Shvartzman-Cohen R. (ref31/cit31) 2004; 126 Wang Y. B. (ref28/cit28) 2006; 128 Liu Z. (ref3/cit3) 2009; 2 Han J. H. (ref45/cit45) 2008; 20 Shvedova A. A. (ref8/cit8) 2008; 295 Tschopp J. (ref27/cit27) 2010; 10 Seo J. W. T. (ref34/cit34) 2011; 2 Arutyunyan N. R. (ref35/cit35) 2010; 75 Porter D. W. (ref12/cit12) 2010; 269 Wang X. (ref18/cit18) 2009; 9
References_xml	– volume: 311 start-page: 622 issue: 5761 year: 2006 ident: ref2/cit2 publication-title: Science doi: 10.1126/science.1114397 – volume: 2 start-page: 8 year: 2005 ident: ref7/cit7 publication-title: Part. Fibre Toxicol. doi: 10.1186/1743-8977-2-8 – volume: 30 start-page: 1906 issue: 11 year: 2009 ident: ref39/cit39 publication-title: Electrophoresis doi: 10.1002/elps.200800737 – volume: 320 start-page: 674 issue: 5876 year: 2008 ident: ref26/cit26 publication-title: Science doi: 10.1126/science.1156995 – volume: 126 start-page: 14850 issue: 45 year: 2004 ident: ref31/cit31 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja046377c – volume: 289 start-page: L698 issue: 5 year: 2005 ident: ref24/cit24 publication-title: Am. J. Physiol. – volume: 5 start-page: 9772 issue: 12 year: 2011 ident: ref21/cit21 publication-title: ACS Nano doi: 10.1021/nn2033055 – volume: 9 start-page: 45 year: 2011 ident: ref38/cit38 publication-title: J. Nanobiotechnol. doi: 10.1186/1477-3155-9-45 – volume: 10 start-page: 210 issue: 3 year: 2010 ident: ref27/cit27 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2725 – volume: 295 start-page: L552 issue: 4 year: 2008 ident: ref8/cit8 publication-title: Am. J. Physiol. – volume: 77 start-page: 126 issue: 1 year: 2004 ident: ref16/cit16 publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfg243 – volume: 10 start-page: 1664 issue: 5 year: 2010 ident: ref25/cit25 publication-title: Nano Lett. doi: 10.1021/nl9042483 – volume: 75 start-page: 163 issue: 2 year: 2010 ident: ref35/cit35 publication-title: Eur. Phys. J. B doi: 10.1140/epjb/e2010-00093-6 – volume: 108 start-page: 16968 issue: 41 year: 2011 ident: ref43/cit43 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1105270108 – start-page: 7 year: 2010 ident: ref15/cit15 publication-title: Part. Fibre Toxicol. – volume: 49 start-page: 1797 issue: 5 year: 2011 ident: ref42/cit42 publication-title: Carbon doi: 10.1016/j.carbon.2011.01.003 – start-page: 6 year: 2009 ident: ref36/cit36 publication-title: Part. Fibre Toxicol. – volume: 178 start-page: 2587 issue: 6 year: 2011 ident: ref19/cit19 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2011.02.040 – volume: 17 start-page: 11 year: 2009 ident: ref30/cit30 publication-title: Fullerenes, Nanotubes, Carbon Nanostruct. doi: 10.1080/15363830802515840 – volume: 117 start-page: 1116 issue: 7 year: 2009 ident: ref48/cit48 publication-title: Environ. Health Persp. doi: 10.1289/ehp.0800319 – volume: 297 start-page: 787 issue: 5582 year: 2002 ident: ref1/cit1 publication-title: Science doi: 10.1126/science.1060928 – volume: 6 start-page: 235 issue: 2 year: 1992 ident: ref46/cit46 publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/ajrcmb/6.2.235 – volume: 77 start-page: 117 issue: 1 year: 2004 ident: ref17/cit17 publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfg228 – volume: 27 start-page: 751 issue: 2 year: 2011 ident: ref29/cit29 publication-title: Langmuir doi: 10.1021/la103096n – volume: 7 start-page: 2348 issue: 16 year: 2011 ident: ref37/cit37 publication-title: Small doi: 10.1002/smll.201100437 – volume: 22 start-page: 369 issue: 5 year: 2010 ident: ref6/cit6 publication-title: Inhal. Toxicol. doi: 10.3109/08958370903367359 – volume: 3 start-page: 15 year: 2010 ident: ref23/cit23 publication-title: Fibrog Tissue Repair doi: 10.1186/1755-1536-3-15 – volume: 4 start-page: 7241 issue: 12 year: 2010 ident: ref20/cit20 publication-title: ACS Nano doi: 10.1021/nn102112b – volume: 4 start-page: 4872 issue: 8 year: 2010 ident: ref44/cit44 publication-title: ACS Nano doi: 10.1021/nn101151x – volume: 15 start-page: 255 issue: 4 year: 2004 ident: ref22/cit22 publication-title: Cytokine Growth Factor Rev. doi: 10.1016/j.cytogfr.2004.03.006 – volume: 20 start-page: 741 issue: 8 year: 2008 ident: ref45/cit45 publication-title: Inhal. Toxicol. doi: 10.1080/08958370801942238 – volume: 5 start-page: 6861 issue: 9 year: 2011 ident: ref11/cit11 publication-title: ACS Nano doi: 10.1021/nn200595c – volume: 5 start-page: 1223 issue: 2 year: 2011 ident: ref47/cit47 publication-title: ACS Nano doi: 10.1021/nn1028482 – volume: 39 start-page: 1378 issue: 5 year: 2005 ident: ref9/cit9 publication-title: Environ. Sci. Technol. doi: 10.1021/es048729l – volume: 4 start-page: 4725 issue: 8 year: 2010 ident: ref33/cit33 publication-title: ACS Nano doi: 10.1021/nn101363m – volume: 128 start-page: 95 issue: 1 year: 2006 ident: ref28/cit28 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja053003q – volume: 269 start-page: 136 issue: 2 year: 2010 ident: ref12/cit12 publication-title: Toxicology doi: 10.1016/j.tox.2009.10.017 – volume: 2 start-page: 1004 issue: 9 year: 2011 ident: ref34/cit34 publication-title: J. Phys. Chem. Lett. doi: 10.1021/jz2003556 – volume: 3 start-page: 387 issue: 7 year: 2008 ident: ref4/cit4 publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2008.135 – volume: 21 start-page: 1698 issue: 9 year: 2008 ident: ref5/cit5 publication-title: Chem. Res. Toxicol. doi: 10.1021/tx800101p – volume: 20 start-page: 82 issue: 1 year: 2006 ident: ref40/cit40 publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2005.06.031 – volume: 4 start-page: 1399 issue: 3 year: 2010 ident: ref41/cit41 publication-title: ACS Nano doi: 10.1021/nn9011225 – volume: 11 start-page: 5201 issue: 12 year: 2011 ident: ref32/cit32 publication-title: Nano Lett. doi: 10.1021/nl202515a – volume: 2 start-page: 85 issue: 2 year: 2009 ident: ref3/cit3 publication-title: Nano Res. doi: 10.1007/s12274-009-9009-8 – volume: 4 start-page: 747 issue: 11 year: 2009 ident: ref13/cit13 publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2009.305 – volume: 294 start-page: L87 issue: 1 year: 2008 ident: ref10/cit10 publication-title: Am. J. Physiol. – volume: 108 start-page: E1330 issue: 49 year: 2011 ident: ref14/cit14 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1110013108 – volume: 9 start-page: 3025 issue: 5 year: 2009 ident: ref18/cit18 publication-title: J. Nanosci. Nanotechnol. doi: 10.1166/jnn.2009.025
SSID	ssj0009350
Score	2.4597344
Snippet	We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability... We compared the use of bovine serum albumin (BSA) and Pluronic F108 (PF108) as dispersants for multi-walled carbon nanotubes (MWCNTs) in terms of tube...
SourceID	pubmedcentral proquest pubmed pascalfrancis crossref acs
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	3050
SubjectTerms	Administration, Inhalation Animals Cellular Coated Materials, Biocompatible - chemistry Coating Cross-disciplinary physics: materials science; rheology Exact sciences and technology Fibrosis Injury prevention Lysosomes - drug effects Lysosomes - pathology Materials science Mice Multi wall carbon nanotubes Nanocrystalline materials Nanoscale materials and structures: fabrication and characterization Nanostructure Nanotubes Nanotubes, Carbon - toxicity Physics Poloxamer - chemistry Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Serum albumin Surgical implants Tubes
Title	Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury
URI	http://dx.doi.org/10.1021/nl300895y https://www.ncbi.nlm.nih.gov/pubmed/22546002 https://www.proquest.com/docview/1020509638 https://www.proquest.com/docview/1762050599 https://pubmed.ncbi.nlm.nih.gov/PMC4143198
Volume	12
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9QwEB6VcgEhypvwWJnHgUtK7ThxfKy2rAoqqAIq9RbZia22hLhqEtDy6xk7u9tdWMo5YyfxzHi-kcffALyuKpYmpuToSMrGXGY6VpzqmIlKGK2VoqFrycdP2f4R_3CcHm_Aq3-c4DP6tqkTjFMynV6D6yxD5_X4Z_zlklk3CW1Y0XMxD5I5n9MHLQ_1oadsV0LPrXPV4irYoX3FOnz5Z5nkUtyZbMHe_PbOUG7ybbvv9Hb5628yx6t-6Q7cnuFOsjsYyl3YMM09uLnERngffhzWfWDKJZhl52TslC-JJnsBWLamJYgVyQFuDmSCObZrT1ty6DpfbYQTO0vCXd6fqq7JWF1o1xDcuV3Xaxypp-Sz54j18x1MW9e67zjmfXOGGn0AR5N3X8f78awtA2oxy7tYJTvSVJYbhCYZyz2DjbRlIqzFpUqF5anNlM4tbsGGC1uZlFvFDOYuzKCWTPIQNhvXmMdAKsqEZTylVSI5U0KW2tqSsh2hLK8sjWCEeitmbtUW4cSc0WKxgBG8mau0KGek5r63Rr1O9OVC9Hxg8lgnNFqxi4UkZom5zCSP4MXcUAp0RH-6ohrjev9tLHDpJPkVMhh6fOtAKSN4NBjX5Rt8ZwKMTxGIFbNbCHgi8NUnzelJIATnCHqpzJ_8b7Wewg3Ee8xXutHkGWx2F715jpiq06PgU78BPawemA
linkProvider	American Chemical Society
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagHKBCvAvhsRjEgUtK7TgPH6uF1Ra2VQWt1FtkJ7baEuKqTqi2v56xk31VK-CcseOMZzzfyJNvEPpQljSOVMHAkYQOGU9kKBiRIU3LVEkpBPFdS_YPkvEx-3oSn_Q0Oe5fGFiEhZmsv8RfsAuQT3UVQbji8fQ2ugMghDpr3h3-WBDsRr4bKzgwpEM8YzMWoeWhLgIVdiUC3b8QFpShuy4W62DmzWrJpfAzetj1MfIL91UnP7fbRm4X1zc4Hf_vyx6hBz0Kxbud2TxGt1T9BG0ucRM-Rb8Pq9bz5mLIuTM8NMIVSOPPHmZaZTEgRzyBowKPIOM29sziQ9O42iOY2Gjs_-y9ElWFh-JSmhrDOW6aVsJIOcXfHWOsm28ytcaaXzBmrz6H_X2GjkdfjobjsG_SAHuaZE0ooh2uSs0UAJWEZo7PhusiSrUGjcWpZrFOhMw0HMiKpbpUMdOCKshkqILNUtEW2qhNrV4gXBKaaspiUkacUZHyQmpdELqTCs1KTQI0AP3lvZPZ3N-fU5LPFRigj7OdzYue4tx12qjWib6fi150vB7rhAYr5jGXhJwx4wlnAXo3s5cc3NLdtYhamdatjXpmnSj7iwwEItdIkPMAPe9sbPEG16cAolWA0hXrmws4WvDVJ_XZqacHZwCBCc9e_ktbb9Hd8dH-JJ_sHXx7he4BEqSuBo5Er9FGc9mqN4C2GjnwbvYHdLsm-Q
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdgSIgJ8T0IH8UgHnjJmB3nw49TR7VBGRUwaW-RndjaRoirOWHq_nrObpq1UwU85-w49-G7011-h9C7sqRxpAoGhiR0yHgiQ8GIDGlapkpKIYifWvLlMNk_Yp-O4-MuUXT_wsAhLOxkfRHfWfW01B3CAPlQVxG4LB7PbqJbrlznNHp3-P0KZDfyE1nBiCEl4hlbIAktL3VeqLArXujuVFhgiJ5PslgXal7vmFxyQaP76Gt_eN958nO7beR2cXkN1_H_v-4ButdFo3h3rj4P0Q1VP0KbSxiFj9HvSdV6_FwMuXeGh0a4Rmm858NNqyyGCBKP4crAI8i8jT21eGIa14MEGxuN_R--F6Kq8FCcS1NjuM9N00pYKWf4m0OOdfuNZ9ZY8wvWHNRnIOcn6Gj08cdwP-yGNYBsk6wJRbTDVamZgoAloZnDteG6iFKtgWtxqlmsEyEzDRezYqkuVcy0oAoyGqpAYCraQhu1qdUzhEtCU01ZTMqIMypSXkitC0J3UqFZqUmABsDDvDM2m_s6OiV5z8AAvV9INy86qHM3caNaR_q2J53O8T3WEQ1WVKSnhNwx4wlnAXqz0JkczNPVXEStTOvORj3CTpT9hQYckhsoyHmAns717OoNbl4BeK0ApSsa2BM4ePDVJ_XpiYcJZxAKE549_xe3XqPbk71RPj44_PwC3YGAkLpWOBK9RBvNeateQdDVyIG3tD_Yayl8
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pluronic+F108+Coating+Decreases+the+Lung+Fibrosis+Potential+of+Multiwall+Carbon+Nanotubes+by+Reducing+Lysosomal+Injury&rft.jtitle=Nano+letters&rft.au=Wang%2C+Xiang&rft.au=Xia%2C+Tian&rft.au=Duch%2C+Matthew+C&rft.au=Ji%2C+Zhaoxia&rft.date=2012-06-13&rft.pub=American+Chemical+Society&rft.issn=1530-6984&rft.eissn=1530-6992&rft.volume=12&rft.issue=6&rft.spage=3050&rft.epage=3061&rft_id=info:doi/10.1021%2Fnl300895y&rft.externalDocID=a875796086
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1530-6984&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1530-6984&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1530-6984&client=summon