Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

• Published in: Nano letters Vol. 12; no. 6; pp. 3050 - 3061
• Main Authors: Wang, Xiang, Xia, Tian, Duch, Matthew C, Ji, Zhaoxia, Zhang, Haiyuan, Li, Ruibin, Sun, Bingbing, Lin, Sijie, Meng, Huan, Liao, Yu-Pei, Wang, Meiying, Song, Tze-Bin, Yang, Yang, Hersam, Mark C, Nel, André E
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 13.06.2012
• Subjects: Administration, Inhalation; Animals; Cellular; Coated Materials, Biocompatible - chemistry; Coating; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Fibrosis; Injury prevention; Lysosomes - drug effects; Lysosomes - pathology; Materials science; Mice; Multi wall carbon nanotubes; Nanocrystalline materials; Nanoscale materials and structures: fabrication and characterization; Nanostructure; Nanotubes; Nanotubes, Carbon - toxicity; Physics; Poloxamer - chemistry; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - pathology; Pulmonary Fibrosis - prevention & control; Serum albumin; Surgical implants; Tubes; biocompatible; pluronic copolymer; dispersion; lung fibrosis; Multiwalled carbon nanotubes (MWCNTs); In vivo; Multiwalled nanotube; Carbon nanotubes; Serum albumin; Damage; Coatings; Nanostructured materials
• ISSN: 1530-6984; 1530-6992; 1530-6992
• DOI: 10.1021/nl300895y

We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.