Increased Feline Cerebral Blood Flow Induced by Dehydroevodiamine Hydrochloride from Evodia rutaecarpa

• Published in: Journal of natural products (Washington, D.C.) Vol. 57; no. 3; pp. 387 - 389
• Main Authors: Haji, Akira, Momose, Yasunori, Takeda, Ryuji, Nakanishi, Suehiro, Horiuchi, Takahiro, Arisawa, Munehisa
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.03.1994; Glendale, AZ American Society of Pharmacognosy
• Subjects: ACIDE CHLORHYDRIQUE; ACIDO CLORHIDRICO; Alkaloids - isolation & purification; Alkaloids - pharmacology; Anesthesia; Animals; Biological and medical sciences; BLOOD CIRCULATION; BRAIN; Cats; CEREBRAL CORTEX; CEREBRO; Cerebrovascular Circulation - drug effects; CHEMICAL COMPOSITION; CIRCULACION SANGUINEA; CIRCULATION SANGUINE; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; DEBIT; DERIVATIVES; DRUG PLANTS; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; ENCEPHALE; FELIDAE; Female; FEUILLE; FLOW RATE; GASTO; General pharmacology; Hemodynamics - drug effects; HOJAS; HYDROCHLORIC ACID; INDUCTION; LEAVES; Male; Medical sciences; MEDICINAL PLANTS; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; PLANTAS MEDICINALES; PLANTE MEDICINALE; Respiratory Function Tests; RUTACEAE; Tropical medicine; Asia; China; Fissipedia; Regional blood flow; Carnivora; Rutaceae; Central nervous system; Biological activity; Medicinal plant; Vertebrata; Mammalia; Folk medicine; Dicotyledones; Animal; Angiospermae; Cat; Plant origin; Spermatophyta; Hemodynamics; Brain (vertebrata)

Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. Ho...