Increased Feline Cerebral Blood Flow Induced by Dehydroevodiamine Hydrochloride from Evodia rutaecarpa

• Published in: Journal of natural products (Washington, D.C.) Vol. 57; no. 3; pp. 387 - 389
• Main Authors: Haji, Akira, Momose, Yasunori, Takeda, Ryuji, Nakanishi, Suehiro, Horiuchi, Takahiro, Arisawa, Munehisa
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.03.1994; Glendale, AZ American Society of Pharmacognosy
• Subjects: ACIDE CHLORHYDRIQUE; ACIDO CLORHIDRICO; Alkaloids - isolation & purification; Alkaloids - pharmacology; Anesthesia; Animals; Biological and medical sciences; BLOOD CIRCULATION; BRAIN; Cats; CEREBRAL CORTEX; CEREBRO; Cerebrovascular Circulation - drug effects; CHEMICAL COMPOSITION; CIRCULACION SANGUINEA; CIRCULATION SANGUINE; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; DEBIT; DERIVATIVES; DRUG PLANTS; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; ENCEPHALE; FELIDAE; Female; FEUILLE; FLOW RATE; GASTO; General pharmacology; Hemodynamics - drug effects; HOJAS; HYDROCHLORIC ACID; INDUCTION; LEAVES; Male; Medical sciences; MEDICINAL PLANTS; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; PLANTAS MEDICINALES; PLANTE MEDICINALE; Respiratory Function Tests; RUTACEAE; Tropical medicine; Asia; China; Fissipedia; Regional blood flow; Carnivora; Rutaceae; Central nervous system; Biological activity; Medicinal plant; Vertebrata; Mammalia; Folk medicine; Dicotyledones; Animal; Angiospermae; Cat; Plant origin; Spermatophyta; Hemodynamics; Brain (vertebrata)
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50105a009

Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined. These results suggest that the compound selectively increases cerebral blood flow.