Nonalcoholic Steatohepatitis

• Published in: Annual review of medicine Vol. 68; p. 85
• Main Authors: Suzuki, Ayako, Diehl, Anna Mae
• Format: Journal Article
• Language: English
• Published: United States 14.01.2017
• Subjects: Cell Death; Hepatitis - etiology; Hepatocytes - pathology; Hepatocytes - physiology; Humans; Lipid Metabolism; Liver - metabolism; Liver - pathology; Liver Cirrhosis - etiology; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; adaptive mechanisms; nonalcoholic fatty liver disease; hepatic fibrosis; hepatocyte damage; lipotoxicity

Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not...