Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not...

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Published inAnnual review of medicine Vol. 68; p. 85
Main Authors Suzuki, Ayako, Diehl, Anna Mae
Format Journal Article
LanguageEnglish
Published United States 14.01.2017
Subjects
Cell Death
Hepatitis - etiology
Hepatocytes - pathology
Hepatocytes - physiology
Humans
Lipid Metabolism
Liver - metabolism
Liver - pathology
Liver Cirrhosis - etiology
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - metabolism
Non-alcoholic Fatty Liver Disease - pathology
adaptive mechanisms
nonalcoholic fatty liver disease
hepatic fibrosis
hepatocyte damage
lipotoxicity
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Summary:Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH. The factors that determine whether or not NASH progresses to cirrhosis are also unclear. This review summarizes key components of NASH pathogenesis and discusses how inherent and acquired variations in regulation of these processes impact the risk for NASH and NASH cirrhosis.
ISSN:1545-326X
DOI:10.1146/annurev-med-051215-031109