Triterpenoid Saponins from Rubus ellipticus var. obcordatus

• Published in: Journal of natural products (Washington, D.C.) Vol. 72; no. 10; pp. 1755 - 1760
• Main Authors: Li, Wei, Fu, Hongwei, Bai, Hong, Sasaki, Tatsunori, Kato, Hiroyoshi, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 23.10.2009; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: alpha-glucosidase; Biological and medical sciences; chemical structure; chemistry; Chemistry, Medicinal; China; Drugs, Chinese Herbal; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; enzyme inhibition; General pharmacology; Glycoside Hydrolase Inhibitors; human health; Inhibitory Concentration 50; isolation & purification; Life Sciences & Biomedicine; Medical sciences; medicinal plants; medicinal properties; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; pharmacology; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Roots; Plant Roots - chemistry; Plant Sciences; Rosaceae; Rosaceae - chemistry; Rubus; Rubus ellipticus var. obcordatus; rubuside; Saponins; Saponins - chemistry; Saponins - pharmacology; Science & Technology; spectral analysis; Triterpenes; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpenoid saponins; China; Asia; STEM BARK; PLANTS; PENTACYCLIC TRITERPENOIDS; GLUCOSIDES; LEAVES; Pentacyclic compound; Rosaceae; Rubus; Alcohol; Medicinal plant; Saponin; Ester; Hypoglycemic agent; Folk medicine; Dicotyledones; Angiospermae; Ursane derivatives; Terpenoid; Aldose; Enzyme; Pharmacognosy; Enzyme inhibitor; In vitro; Biological activity; Glycosylases; α-Glucosidase; Glycosidases; Plant origin; Triterpene; Hydrolases; Isolation; Spermatophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025; 1520-6025
• DOI: 10.1021/np900237a

Ten new triterpenoid saponins (1−10), named rubusides A−J, and 21 known saponins (11−31) were isolated from the roots of Rubus ellipticus var. obcordatus. The structures of 1−10 were established on the basis of spectroscopic analyses, mainly NMR and MS, and chemical degradations. The compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the range 0.65−3.09 mM.