Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs

• Published in: ACS omega Vol. 7; no. 3; pp. 3073 - 3082
• Main Authors: Zakharova, Lucia Ya, Voloshina, Alexandra D, Ibatullina, Marina R, Zhiltsova, Elena P, Lukashenko, Svetlana S, Kuznetsova, Darya A, Kutyreva, Marianna P, Sapunova, Anastasiia S, Kufelkina, Anna A, Kulik, Natalia V, Kataeva, Olga, Ivshin, Kamil A, Gubaidullin, Aidar T, Salnikov, Vadim V, Nizameev, Irek R, Kadirov, Marsil K, Sinyashin, Oleg G
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.01.2022
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.1c06465

New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]­octane bromide complexes with copper­(II) bromide and lanthanum­(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum­(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revealed against the M-HeLa and A-549 cell lines. Both complexes were 2 times more active toward the MCF-7 cell line than the breast cancer drug tamoxifen. The cytotoxic mechanism of complexes is assumed to be related to the induction of apoptosis through the mitochondrial pathway.