Catalysis in a Cationic Coordination Cage Using a Cavity-Bound Guest and Surface-Bound Anions: Inhibition, Activation, and Autocatalysis

• Published in: Journal of the American Chemical Society Vol. 140; no. 8; pp. 2821 - 2828
• Main Authors: Cullen, William, Metherell, Alexander J, Wragg, Ashley B, Taylor, Christopher G. P, Williams, Nicholas H, Ward, Michael D
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.02.2018

The Kemp elimination (reaction of benz­isox­azole with base to give 2-cyanophenolate) is catalyzed in the cavity of a cubic M8L12 coordination cage because of a combination of (i) benz­isox­azole binding in the cage cavity driven by the hydrophobic effect, and (ii) accumulation of hydroxide ions aro...